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Hyperhomocysteinemia potentiates megakaryocyte differentiation and thrombopoiesis via GH-PI3K-Akt axis

Hyperhomocysteinemia (HHcy) is closely associated with thrombotic diseases such as myocardial infarction and stroke. Enhanced platelet activation was observed in animals and humans with HHcy. However, the influence of HHcy on thrombopoiesis remains largely unknown. Here, we reported increased platel...

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Detalles Bibliográficos
Autores principales: Lei, Wenjing, Liu, Zhuoliang, Su, Zhiyuan, Meng, Panpan, Zhou, Chun, Chen, Xiaomei, Hu, Zheng, Xiao, An, Zhou, Miaomiao, Huang, Liping, Zhang, Yiyue, Qin, Xianhui, Wang, Junping, Zhu, Fengxin, Nie, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373258/
https://www.ncbi.nlm.nih.gov/pubmed/37501059
http://dx.doi.org/10.1186/s13045-023-01481-x