Immunostimulatory gene therapy targeting CD40, 4-1BB and IL-2R activates DCs and stimulates antigen-specific T-cell and NK-cell responses in melanoma models

BACKGROUND: The activation of dendritic cells (DCs) is pivotal for generating antigen-specific T-cell responses to eradicate tumor cells. Hence, immunotherapies targeting this interplay are especially intriguing. Moreover, it is of interest to modulate the tumor microenvironment (TME), as this harsh...

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Detalles Bibliográficos
Autores principales: Wenthe, Jessica, Eriksson, Emma, Hellström, Ann-Charlotte, Moreno, Rafael, Ullenhag, Gustav, Alemany, Ramon, Lövgren, Tanja, Loskog, Angelica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373363/
https://www.ncbi.nlm.nih.gov/pubmed/37501121
http://dx.doi.org/10.1186/s12967-023-04374-2

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