A high-throughput screening system for SARS-CoV-2 entry inhibition, syncytia formation and cell toxicity

BACKGROUND: The entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the host cell is mediated through the binding of the SARS-CoV-2 Spike protein via the receptor binding domain (RBD) to human angiotensin-converting enzyme 2 (hACE2). Identifying compounds that inhibit Spike-AC...

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Detalles Bibliográficos
Autores principales: Jancy, Shine Varghese, Lupitha, Santhik Subhasingh, Chandrasekharan, Aneesh, Varadarajan, Shankara Narayanan, Nelson-Sathi, Shijulal, Prasad, Roshny, Jones, Sara, Easwaran, Sreekumar, Darvin, Pramod, Sivasailam, Aswathy, Santhoshkumar, Thankayyan Retnabai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373420/
https://www.ncbi.nlm.nih.gov/pubmed/37495994
http://dx.doi.org/10.1186/s12575-023-00214-1

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