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Modified Tacrine Derivatives as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease: Synthesis, Biological Evaluation, and Molecular Modeling Study

[Image: see text] To develop multitarget-directed ligands (MTDLs) as potential treatments for Alzheimer’s disease (AD) and to shed light on the effect of the chromene group in designing these ligands, 35 new tacrine-chromene derivatives were designed, synthesized, and biologically evaluated. Compoun...

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Detalles Bibliográficos
Autores principales:	Fares, Salma, El Husseiny, Walaa M., Selim, Khalid B., Massoud, Mohammed A. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373466/ https://www.ncbi.nlm.nih.gov/pubmed/37521639 http://dx.doi.org/10.1021/acsomega.3c02051

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