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Host insulin resistance caused by Porphyromonas gingivalis-review of recent progresses
Porphyromonas gingivalis (P. gingivalis) is a Gram-negative oral anaerobic bacterium that plays a key role in the pathogenesis of periodontitis. P. gingivalis expresses a variety of virulence factors that disrupt innate and adaptive immunity, allowing P. gingivalis to survive and multiply in the hos...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373507/ https://www.ncbi.nlm.nih.gov/pubmed/37520442 http://dx.doi.org/10.3389/fcimb.2023.1209381 |
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author | Jia, Shuxian Li, Xiaobing Du, Qin |
author_facet | Jia, Shuxian Li, Xiaobing Du, Qin |
author_sort | Jia, Shuxian |
collection | PubMed |
description | Porphyromonas gingivalis (P. gingivalis) is a Gram-negative oral anaerobic bacterium that plays a key role in the pathogenesis of periodontitis. P. gingivalis expresses a variety of virulence factors that disrupt innate and adaptive immunity, allowing P. gingivalis to survive and multiply in the host and destroy periodontal tissue. In addition to periodontal disease, P.gingivalis is also associated with systemic diseases, of which insulin resistance is an important pathological basis. P. gingivalis causes a systemic inflammatory response, disrupts insulin signaling pathways, induces pancreatic β-cell hypofunction and reduced numbers, and causes decreased insulin sensitivity leading to insulin resistance (IR). In this paper, we systematically review the studies on the mechanism of insulin resistance induced by P. gingivalis, discuss the association between P. gingivalis and systemic diseases based on insulin resistance, and finally propose relevant therapeutic approaches. Overall, through a systematic review of the mechanisms related to systemic diseases caused by P. gingivalis through insulin resistance, we hope to provide new insights for future basic research and clinical interventions for related systemic diseases. |
format | Online Article Text |
id | pubmed-10373507 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103735072023-07-28 Host insulin resistance caused by Porphyromonas gingivalis-review of recent progresses Jia, Shuxian Li, Xiaobing Du, Qin Front Cell Infect Microbiol Cellular and Infection Microbiology Porphyromonas gingivalis (P. gingivalis) is a Gram-negative oral anaerobic bacterium that plays a key role in the pathogenesis of periodontitis. P. gingivalis expresses a variety of virulence factors that disrupt innate and adaptive immunity, allowing P. gingivalis to survive and multiply in the host and destroy periodontal tissue. In addition to periodontal disease, P.gingivalis is also associated with systemic diseases, of which insulin resistance is an important pathological basis. P. gingivalis causes a systemic inflammatory response, disrupts insulin signaling pathways, induces pancreatic β-cell hypofunction and reduced numbers, and causes decreased insulin sensitivity leading to insulin resistance (IR). In this paper, we systematically review the studies on the mechanism of insulin resistance induced by P. gingivalis, discuss the association between P. gingivalis and systemic diseases based on insulin resistance, and finally propose relevant therapeutic approaches. Overall, through a systematic review of the mechanisms related to systemic diseases caused by P. gingivalis through insulin resistance, we hope to provide new insights for future basic research and clinical interventions for related systemic diseases. Frontiers Media S.A. 2023-07-13 /pmc/articles/PMC10373507/ /pubmed/37520442 http://dx.doi.org/10.3389/fcimb.2023.1209381 Text en Copyright © 2023 Jia, Li and Du https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Jia, Shuxian Li, Xiaobing Du, Qin Host insulin resistance caused by Porphyromonas gingivalis-review of recent progresses |
title | Host insulin resistance caused by Porphyromonas gingivalis-review of recent progresses |
title_full | Host insulin resistance caused by Porphyromonas gingivalis-review of recent progresses |
title_fullStr | Host insulin resistance caused by Porphyromonas gingivalis-review of recent progresses |
title_full_unstemmed | Host insulin resistance caused by Porphyromonas gingivalis-review of recent progresses |
title_short | Host insulin resistance caused by Porphyromonas gingivalis-review of recent progresses |
title_sort | host insulin resistance caused by porphyromonas gingivalis-review of recent progresses |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373507/ https://www.ncbi.nlm.nih.gov/pubmed/37520442 http://dx.doi.org/10.3389/fcimb.2023.1209381 |
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