Cargando…

Host insulin resistance caused by Porphyromonas gingivalis-review of recent progresses

Porphyromonas gingivalis (P. gingivalis) is a Gram-negative oral anaerobic bacterium that plays a key role in the pathogenesis of periodontitis. P. gingivalis expresses a variety of virulence factors that disrupt innate and adaptive immunity, allowing P. gingivalis to survive and multiply in the hos...

Descripción completa

Detalles Bibliográficos
Autores principales: Jia, Shuxian, Li, Xiaobing, Du, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373507/
https://www.ncbi.nlm.nih.gov/pubmed/37520442
http://dx.doi.org/10.3389/fcimb.2023.1209381
_version_ 1785078583488675840
author Jia, Shuxian
Li, Xiaobing
Du, Qin
author_facet Jia, Shuxian
Li, Xiaobing
Du, Qin
author_sort Jia, Shuxian
collection PubMed
description Porphyromonas gingivalis (P. gingivalis) is a Gram-negative oral anaerobic bacterium that plays a key role in the pathogenesis of periodontitis. P. gingivalis expresses a variety of virulence factors that disrupt innate and adaptive immunity, allowing P. gingivalis to survive and multiply in the host and destroy periodontal tissue. In addition to periodontal disease, P.gingivalis is also associated with systemic diseases, of which insulin resistance is an important pathological basis. P. gingivalis causes a systemic inflammatory response, disrupts insulin signaling pathways, induces pancreatic β-cell hypofunction and reduced numbers, and causes decreased insulin sensitivity leading to insulin resistance (IR). In this paper, we systematically review the studies on the mechanism of insulin resistance induced by P. gingivalis, discuss the association between P. gingivalis and systemic diseases based on insulin resistance, and finally propose relevant therapeutic approaches. Overall, through a systematic review of the mechanisms related to systemic diseases caused by P. gingivalis through insulin resistance, we hope to provide new insights for future basic research and clinical interventions for related systemic diseases.
format Online
Article
Text
id pubmed-10373507
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-103735072023-07-28 Host insulin resistance caused by Porphyromonas gingivalis-review of recent progresses Jia, Shuxian Li, Xiaobing Du, Qin Front Cell Infect Microbiol Cellular and Infection Microbiology Porphyromonas gingivalis (P. gingivalis) is a Gram-negative oral anaerobic bacterium that plays a key role in the pathogenesis of periodontitis. P. gingivalis expresses a variety of virulence factors that disrupt innate and adaptive immunity, allowing P. gingivalis to survive and multiply in the host and destroy periodontal tissue. In addition to periodontal disease, P.gingivalis is also associated with systemic diseases, of which insulin resistance is an important pathological basis. P. gingivalis causes a systemic inflammatory response, disrupts insulin signaling pathways, induces pancreatic β-cell hypofunction and reduced numbers, and causes decreased insulin sensitivity leading to insulin resistance (IR). In this paper, we systematically review the studies on the mechanism of insulin resistance induced by P. gingivalis, discuss the association between P. gingivalis and systemic diseases based on insulin resistance, and finally propose relevant therapeutic approaches. Overall, through a systematic review of the mechanisms related to systemic diseases caused by P. gingivalis through insulin resistance, we hope to provide new insights for future basic research and clinical interventions for related systemic diseases. Frontiers Media S.A. 2023-07-13 /pmc/articles/PMC10373507/ /pubmed/37520442 http://dx.doi.org/10.3389/fcimb.2023.1209381 Text en Copyright © 2023 Jia, Li and Du https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Jia, Shuxian
Li, Xiaobing
Du, Qin
Host insulin resistance caused by Porphyromonas gingivalis-review of recent progresses
title Host insulin resistance caused by Porphyromonas gingivalis-review of recent progresses
title_full Host insulin resistance caused by Porphyromonas gingivalis-review of recent progresses
title_fullStr Host insulin resistance caused by Porphyromonas gingivalis-review of recent progresses
title_full_unstemmed Host insulin resistance caused by Porphyromonas gingivalis-review of recent progresses
title_short Host insulin resistance caused by Porphyromonas gingivalis-review of recent progresses
title_sort host insulin resistance caused by porphyromonas gingivalis-review of recent progresses
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373507/
https://www.ncbi.nlm.nih.gov/pubmed/37520442
http://dx.doi.org/10.3389/fcimb.2023.1209381
work_keys_str_mv AT jiashuxian hostinsulinresistancecausedbyporphyromonasgingivalisreviewofrecentprogresses
AT lixiaobing hostinsulinresistancecausedbyporphyromonasgingivalisreviewofrecentprogresses
AT duqin hostinsulinresistancecausedbyporphyromonasgingivalisreviewofrecentprogresses