Chemically induced reprogramming to reverse cellular aging

A hallmark of eukaryotic aging is a loss of epigenetic information, a process that can be reversed. We have previously shown that the ectopic induction of the Yamanaka factors OCT4, SOX2, and KLF4 (OSK) in mammals can restore youthful DNA methylation patterns, transcript profiles, and tissue functio...

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Detalles Bibliográficos
Autores principales: Yang, Jae-Hyun, Petty, Christopher A., Dixon-McDougall, Thomas, Lopez, Maria Vina, Tyshkovskiy, Alexander, Maybury-Lewis, Sun, Tian, Xiao, Ibrahim, Nabilah, Chen, Zhili, Griffin, Patrick T., Arnold, Matthew, Li, Jien, Martinez, Oswaldo A., Behn, Alexander, Rogers-Hammond, Ryan, Angeli, Suzanne, Gladyshev, Vadim N., Sinclair, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2023
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373966/
https://www.ncbi.nlm.nih.gov/pubmed/37437248
http://dx.doi.org/10.18632/aging.204896

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