Budding uninhibited by benzimidazoles-1 (BUB1) regulates EGFR signaling by reducing EGFR internalization

EGFR signaling initiates upon ligand binding which leads to activation and internalization of the receptor-ligand complex. Here, we evaluated if BUB1 impacted EGFR signaling by regulating EGFR receptor internalization and activation. BUB1 was ablated genomically (siRNA) or biochemically (2OH-BNPP1)...

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Detalles Bibliográficos
Autores principales: Nyati, Shyam, Young, Grant, Speers, Corey, Nyati, Mukesh K., Rehemtulla, Alnawaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373970/
https://www.ncbi.nlm.nih.gov/pubmed/37399454
http://dx.doi.org/10.18632/aging.204820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373970/
https://www.ncbi.nlm.nih.gov/pubmed/37399454
http://dx.doi.org/10.18632/aging.204820

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