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Class I histone deacetylase complex: Structure and functional correlates

The Schizosaccharomyces pombe Clr6S complex, a class I histone deacetylase complex, functions as a zinc-dependent enzyme to remove acetyl groups from lysine residues in histone tails. We report here the cryo-EM structure of Clr6S alone and a cryo-EM map of Clr6S in complex with a nucleosome. The act...

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Detalles Bibliográficos
Autores principales:	Wang, Xiao, Wang, Yannan, Liu, Simiao, Zhang, Yi, Xu, Ke, Ji, Liting, Kornberg, Roger D., Zhang, Heqiao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374167/ https://www.ncbi.nlm.nih.gov/pubmed/37459529 http://dx.doi.org/10.1073/pnas.2307598120

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