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Early development history of Botox (onabotulinumtoxinA)
The development of Botox (onabotulinumtoxinA) began in the 1970s as Dr. Scott was attempting to identify an injectable substance that would weaken the extraocular eye muscles in patients with strabismus as an alternative to muscle surgery. This search led to botulinum toxin type A, which was tested...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374179/ https://www.ncbi.nlm.nih.gov/pubmed/37499077 http://dx.doi.org/10.1097/MD.0000000000032371 |
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author | Scott, Alan B. Honeychurch, Dennis Brin, Mitchell F. |
author_facet | Scott, Alan B. Honeychurch, Dennis Brin, Mitchell F. |
author_sort | Scott, Alan B. |
collection | PubMed |
description | The development of Botox (onabotulinumtoxinA) began in the 1970s as Dr. Scott was attempting to identify an injectable substance that would weaken the extraocular eye muscles in patients with strabismus as an alternative to muscle surgery. This search led to botulinum toxin type A, which was tested and developed over the next 15 years. As botulinum toxin type A moved from an experimental drug to a product in need of licensing by the Food and Drug Administration (FDA), the first manufacturing methods and quality control procedures were developed for Oculinum, the botulinum toxin type A product that would eventually be sold to Allergan and become known as Botox. |
format | Online Article Text |
id | pubmed-10374179 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-103741792023-07-28 Early development history of Botox (onabotulinumtoxinA) Scott, Alan B. Honeychurch, Dennis Brin, Mitchell F. Medicine (Baltimore) OA Supplement Article The development of Botox (onabotulinumtoxinA) began in the 1970s as Dr. Scott was attempting to identify an injectable substance that would weaken the extraocular eye muscles in patients with strabismus as an alternative to muscle surgery. This search led to botulinum toxin type A, which was tested and developed over the next 15 years. As botulinum toxin type A moved from an experimental drug to a product in need of licensing by the Food and Drug Administration (FDA), the first manufacturing methods and quality control procedures were developed for Oculinum, the botulinum toxin type A product that would eventually be sold to Allergan and become known as Botox. Lippincott Williams & Wilkins 2023-07-01 /pmc/articles/PMC10374179/ /pubmed/37499077 http://dx.doi.org/10.1097/MD.0000000000032371 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | OA Supplement Article Scott, Alan B. Honeychurch, Dennis Brin, Mitchell F. Early development history of Botox (onabotulinumtoxinA) |
title | Early development history of Botox (onabotulinumtoxinA) |
title_full | Early development history of Botox (onabotulinumtoxinA) |
title_fullStr | Early development history of Botox (onabotulinumtoxinA) |
title_full_unstemmed | Early development history of Botox (onabotulinumtoxinA) |
title_short | Early development history of Botox (onabotulinumtoxinA) |
title_sort | early development history of botox (onabotulinumtoxina) |
topic | OA Supplement Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374179/ https://www.ncbi.nlm.nih.gov/pubmed/37499077 http://dx.doi.org/10.1097/MD.0000000000032371 |
work_keys_str_mv | AT scottalanb earlydevelopmenthistoryofbotoxonabotulinumtoxina AT honeychurchdennis earlydevelopmenthistoryofbotoxonabotulinumtoxina AT brinmitchellf earlydevelopmenthistoryofbotoxonabotulinumtoxina |