Integrative dynamic structural biology unveils conformers essential for the oligomerization of a large GTPase

Guanylate binding proteins (GBPs) are soluble dynamin-like proteins that undergo a conformational transition for GTP-controlled oligomerization and disrupt membranes of intracellular parasites to exert their function as part of the innate immune system of mammalian cells. We apply neutron spin echo,...

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Detalles Bibliográficos
Autores principales: Peulen, Thomas-O, Hengstenberg, Carola S, Biehl, Ralf, Dimura, Mykola, Lorenz, Charlotte, Valeri, Alessandro, Folz, Julian, Hanke, Christian A, Ince, Semra, Vöpel, Tobias, Farago, Bela, Gohlke, Holger, Klare, Johann P, Stadler, Andreas M, Seidel, Claus AM, Herrmann, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374282/
https://www.ncbi.nlm.nih.gov/pubmed/37314846
http://dx.doi.org/10.7554/eLife.79565

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