Cargando…

Hormonal contraceptive exposure relates to changes in resting state functional connectivity of anterior cingulate cortex and amygdala

INTRODUCTION: Hormonal contraceptives (HCs), nowadays one of the most used contraceptive methods, downregulate endogenous ovarian hormones, which have multiple plastic effects in the adult brain. HCs usually contain a synthetic estrogen, ethinyl-estradiol, and a synthetic progestin, which can be cla...

Descripción completa

Detalles Bibliográficos
Autores principales: Hidalgo-Lopez, Esmeralda, Noachtar, Isabel, Pletzer, Belinda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374315/
https://www.ncbi.nlm.nih.gov/pubmed/37522123
http://dx.doi.org/10.3389/fendo.2023.1131995
_version_ 1785078747761737728
author Hidalgo-Lopez, Esmeralda
Noachtar, Isabel
Pletzer, Belinda
author_facet Hidalgo-Lopez, Esmeralda
Noachtar, Isabel
Pletzer, Belinda
author_sort Hidalgo-Lopez, Esmeralda
collection PubMed
description INTRODUCTION: Hormonal contraceptives (HCs), nowadays one of the most used contraceptive methods, downregulate endogenous ovarian hormones, which have multiple plastic effects in the adult brain. HCs usually contain a synthetic estrogen, ethinyl-estradiol, and a synthetic progestin, which can be classified as androgenic or anti-androgenic, depending on their interaction with androgen receptors. Both the anterior cingulate cortex (ACC) and the amygdala express steroid receptors and have shown differential functionality depending on the hormonal status of the participant and the use of HC. In this work, we investigated for the first time the relationship between ACC and amygdala resting state functional connectivity (rs-FC) and HC use duration, while controlling for progestin androgenicity. METHODS: A total of 231 healthy young women participated in five different magnetic resonance imaging studies and were included in the final analysis. The relation between HC use duration and (i) gray matter volume, (ii) fractional amplitude of low-frequency fluctuations, and (iii) seed-based connectivity during resting state in the amygdalae and ACC was investigated in this large sample of women. RESULTS: In general, rs-FC of the amygdalae with frontal areas, and between the ACC and temporoparietal areas, decreased the longer the HC exposure and independently of the progestin’s androgenicity. The type of HC’s progestin did show a differential effect in the gray matter volume of left ACC and the connectivity between bilateral ACC and the right inferior frontal gyrus.
format Online
Article
Text
id pubmed-10374315
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-103743152023-07-28 Hormonal contraceptive exposure relates to changes in resting state functional connectivity of anterior cingulate cortex and amygdala Hidalgo-Lopez, Esmeralda Noachtar, Isabel Pletzer, Belinda Front Endocrinol (Lausanne) Endocrinology INTRODUCTION: Hormonal contraceptives (HCs), nowadays one of the most used contraceptive methods, downregulate endogenous ovarian hormones, which have multiple plastic effects in the adult brain. HCs usually contain a synthetic estrogen, ethinyl-estradiol, and a synthetic progestin, which can be classified as androgenic or anti-androgenic, depending on their interaction with androgen receptors. Both the anterior cingulate cortex (ACC) and the amygdala express steroid receptors and have shown differential functionality depending on the hormonal status of the participant and the use of HC. In this work, we investigated for the first time the relationship between ACC and amygdala resting state functional connectivity (rs-FC) and HC use duration, while controlling for progestin androgenicity. METHODS: A total of 231 healthy young women participated in five different magnetic resonance imaging studies and were included in the final analysis. The relation between HC use duration and (i) gray matter volume, (ii) fractional amplitude of low-frequency fluctuations, and (iii) seed-based connectivity during resting state in the amygdalae and ACC was investigated in this large sample of women. RESULTS: In general, rs-FC of the amygdalae with frontal areas, and between the ACC and temporoparietal areas, decreased the longer the HC exposure and independently of the progestin’s androgenicity. The type of HC’s progestin did show a differential effect in the gray matter volume of left ACC and the connectivity between bilateral ACC and the right inferior frontal gyrus. Frontiers Media S.A. 2023-07-13 /pmc/articles/PMC10374315/ /pubmed/37522123 http://dx.doi.org/10.3389/fendo.2023.1131995 Text en Copyright © 2023 Hidalgo-Lopez, Noachtar and Pletzer https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Hidalgo-Lopez, Esmeralda
Noachtar, Isabel
Pletzer, Belinda
Hormonal contraceptive exposure relates to changes in resting state functional connectivity of anterior cingulate cortex and amygdala
title Hormonal contraceptive exposure relates to changes in resting state functional connectivity of anterior cingulate cortex and amygdala
title_full Hormonal contraceptive exposure relates to changes in resting state functional connectivity of anterior cingulate cortex and amygdala
title_fullStr Hormonal contraceptive exposure relates to changes in resting state functional connectivity of anterior cingulate cortex and amygdala
title_full_unstemmed Hormonal contraceptive exposure relates to changes in resting state functional connectivity of anterior cingulate cortex and amygdala
title_short Hormonal contraceptive exposure relates to changes in resting state functional connectivity of anterior cingulate cortex and amygdala
title_sort hormonal contraceptive exposure relates to changes in resting state functional connectivity of anterior cingulate cortex and amygdala
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374315/
https://www.ncbi.nlm.nih.gov/pubmed/37522123
http://dx.doi.org/10.3389/fendo.2023.1131995
work_keys_str_mv AT hidalgolopezesmeralda hormonalcontraceptiveexposurerelatestochangesinrestingstatefunctionalconnectivityofanteriorcingulatecortexandamygdala
AT noachtarisabel hormonalcontraceptiveexposurerelatestochangesinrestingstatefunctionalconnectivityofanteriorcingulatecortexandamygdala
AT pletzerbelinda hormonalcontraceptiveexposurerelatestochangesinrestingstatefunctionalconnectivityofanteriorcingulatecortexandamygdala