Cargando…

miR-145 Alleviates Smooth Muscle Cell Phenotype Transition via ADAM17-Mediated ACE2 Shedding

It has been shown that miR-145 is involved in the differentiation of vascular smooth muscle cells (VSMCs) and may regulate vascular remodeling. However, the molecular mechanisms behind these pathological processes in hypertension are not fully elucidated. The present study was to examine whether miR...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wen, Juan, Tang, Baiyi, Guo, Lan, Chen, Wei, Tang, Xiaohong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374374/ https://www.ncbi.nlm.nih.gov/pubmed/37521117 http://dx.doi.org/10.1155/2023/9497716

Ejemplares similares

A model for COVID-19-induced dysregulation of ACE2 shedding by ADAM17
por: Healy, Eamonn F., et al.
Publicado: (2021)

ADAM17 knockdown mitigates while ADAM17 overexpression aggravates cardiac fibrosis and dysfunction via regulating ACE2 shedding and myofibroblast transformation
por: Cheng, Jing, et al.
Publicado: (2022)

MiR-145 reduces ADAM17 expression and inhibits in vitro migration and invasion of glioma cells
por: LU, YONG, et al.
Publicado: (2012)

The collectrin‐like part of the SARS‐CoV‐1 and ‐2 receptor ACE2 is shed by the metalloproteinases ADAM10 and ADAM17
por: Niehues, Rabea Victoria, et al.
Publicado: (2022)

Activation of Kinin B1R Upregulates ADAM17 and Results in ACE2 Shedding in Neurons
por: Parekh, Rohan Umesh, et al.
Publicado: (2020)

MiR-145 inhibits the epithelial-to-mesenchymal transition via targeting ADAM19 in human glioblastoma
por: Wang, Xingqiang, et al.
Publicado: (2017)

ADAM17 Confers Temozolomide Resistance in Human Glioblastoma Cells and miR-145 Regulates Its Expression
por: Yang, Jen-Tsung, et al.
Publicado: (2023)

Dynamics of ADAM17-Mediated Shedding of ACE2 Applied to Pancreatic Islets of Male db/db Mice
por: Pedersen, Kim Brint, et al.
Publicado: (2015)

LRP1 shedding in human brain: roles of ADAM10 and ADAM17
por: Liu, Qiang, et al.
Publicado: (2009)

ADAM17-Mediated Shedding of Inflammatory Cytokines in Hypertension
por: de Queiroz, Thyago M., et al.
Publicado: (2020)

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
por: Sahin, Umut, et al.
Publicado: (2004)

ADAM10 mediates shedding of carbonic anhydrase IX ectodomain non-redundantly to ADAM17
por: Zatovicova, Miriam, et al.
Publicado: (2022)

How tetraspanin-mediated cell entry of SARS-CoV-2 can dysregulate the shedding of the ACE2 receptor by ADAM17
por: Healy, Eamonn F.
Publicado: (2022)

ADAM17 is essential for ectodomain shedding of the EGF‐receptor ligand amphiregulin
por: Hosur, Vishnu, et al.
Publicado: (2018)

Involvement of shedding induced by ADAM17 on the nitric oxide pathway in hypertension
por: da Silva, Mirelly Cunha, et al.
Publicado: (2022)

miR-145 and miR-143 Regulate Smooth Muscle Cell Fate Decisions
por: Cordes, Kimberly R., et al.
Publicado: (2009)

P38 MAPK activated ADAM17 mediates ACE2 shedding and promotes cardiac remodeling and heart failure after myocardial infarction
por: Chen, Qi, et al.
Publicado: (2023)

miR‐145 attenuates phenotypic transformation of aortic vascular smooth muscle cells to prevent aortic dissection
por: Qiu, Zhi‐Huang, et al.
Publicado: (2021)

Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP
por: Sammel, Martin, et al.
Publicado: (2019)

Increased Complement 3 With Suppression of miR‐145 Induces the Synthetic Phenotype in Vascular Smooth Muscle Cells From Spontaneously Hypertensive Rats
por: Chen, Lan, et al.
Publicado: (2019)

Tetraspanin CD9 modulates ADAM17-mediated shedding of LR11 in leukocytes
por: Tsukamoto, Shokichi, et al.
Publicado: (2014)

ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium
por: Ma, Xiang, et al.
Publicado: (2021)

Phenotypic switching of vascular smooth muscle cells in the ‘normal region’ of aorta from atherosclerosis patients is regulated by miR‐145
por: Zhang, Yu‐nan, et al.
Publicado: (2016)

Lung ACE2 and ADAM17 in pulmonary arterial hypertension: Implications for COVID-19?
por: Pérez-Vizcaíno, Francisco
Publicado: (2020)

Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE
por: Cavadas, Miguel, et al.
Publicado: (2017)

Ectodomain Shedding by ADAM17: Its Role in Neutrophil Recruitment and the Impairment of This Process during Sepsis
por: Mishra, Hemant K., et al.
Publicado: (2017)

ADAM17-mediated EGFR ligand shedding directs macrophage-promoted cancer cell invasion
por: Gnosa, Sebastian P., et al.
Publicado: (2022)

miR‐145 inhibits the proliferation and migration of vascular smooth muscle cells by regulating autophagy
por: Wang, Weirong, et al.
Publicado: (2020)

Therapeutic Response of miR-145 Micelles on Patient-Derived Vascular Smooth Muscle Cells
por: Patel, Neil, et al.
Publicado: (2022)

c-Myb regulates transcriptional activation of miR-143/145 in vascular smooth muscle cells
por: Chandy, Mark, et al.
Publicado: (2018)

Vitamin D3 Prevents the Deleterious Effects of Testicular Torsion on Testis by Targeting miRNA-145 and ADAM17: In Silico and In Vivo Study
por: Mohamed, Doaa I., et al.
Publicado: (2021)

ADAM 17 endopeptidase
Publicado: (2009)

ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19
por: Zipeto, Donato, et al.
Publicado: (2020)

The ADAM15 ectodomain is shed from secretory exosomes
por: Lee, Hee Doo, et al.
Publicado: (2015)

Regulation of ectodomain shedding of ADAM33 in vitro and in vivo
por: Davies, Elizabeth R., et al.
Publicado: (2019)

MiR-145 mediates cell morphology-regulated mesenchymal stem cell differentiation to smooth muscle cells
por: Yeh, Yi-Ting, et al.
Publicado: (2019)

ADAM10 and ADAM17: New Players in Trastuzumab Resistance
por: Duffy, Michael J., et al.
Publicado: (2014)

ADAM10 and ADAM17—Novel Players in Retinoblastoma Carcinogenesis
por: Van Meenen, Dario, et al.
Publicado: (2022)

Role of ADAMs in the Ectodomain Shedding and Conformational Conversion of the Prion Protein
por: Taylor, David R., et al.
Publicado: (2009)

Ectodomain shedding of the hypoxia-induced carbonic anhydrase IX is a metalloprotease-dependent process regulated by TACE/ADAM17
por: Zatovicova, M, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_7q9khcf2jkucomufu4nar61u7g