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Maternal vaccination: shaping the neonatal response to pertussis

Antepartum maternal vaccination can protect highly sensitive newborns before they are old enough to receive their own vaccines. Two vaccines are currently recommended during pregnancy: the flu vaccine and the Tdap vaccine against tetanus, diphtheria, and pertussis. Although there is strong evidence...

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Autores principales: Callender, Maiya, Harvill, Eric T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374427/
https://www.ncbi.nlm.nih.gov/pubmed/37520565
http://dx.doi.org/10.3389/fimmu.2023.1210580
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author Callender, Maiya
Harvill, Eric T.
author_facet Callender, Maiya
Harvill, Eric T.
author_sort Callender, Maiya
collection PubMed
description Antepartum maternal vaccination can protect highly sensitive newborns before they are old enough to receive their own vaccines. Two vaccines are currently recommended during pregnancy: the flu vaccine and the Tdap vaccine against tetanus, diphtheria, and pertussis. Although there is strong evidence that maternal vaccination works to protect the offspring, limitations in the understanding of vaccines and of maternal transfer of immunity compound to obscure our understanding of how they work. Here we focus on the example of pertussis to explore the possible mechanisms involved in the transfer of protection to offspring and how these may impact the newborn’s response to future exposure to pertussis. For example, Tdap vaccines induce pathogen specific antibodies, and those antibodies are known to be transferred from mother to the fetus in utero and to the newborn via milk. But antibodies alone have modest impact on pertussis disease, and even less effect on colonization/transmission. Maternal immune cells can also be transferred to offspring and may play a direct role in protection from disease and/or influence the developing neonatal immune system. However, some of the transferred immunity may also blunt the offspring’s response to subsequent vaccination. In this review we will summarize the protection conferred to offspring by maternal vaccination against pertussis and the likely mechanisms by which protection is transferred, identifying the many knowledge gaps that limit our most effective application of this approach.
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spelling pubmed-103744272023-07-29 Maternal vaccination: shaping the neonatal response to pertussis Callender, Maiya Harvill, Eric T. Front Immunol Immunology Antepartum maternal vaccination can protect highly sensitive newborns before they are old enough to receive their own vaccines. Two vaccines are currently recommended during pregnancy: the flu vaccine and the Tdap vaccine against tetanus, diphtheria, and pertussis. Although there is strong evidence that maternal vaccination works to protect the offspring, limitations in the understanding of vaccines and of maternal transfer of immunity compound to obscure our understanding of how they work. Here we focus on the example of pertussis to explore the possible mechanisms involved in the transfer of protection to offspring and how these may impact the newborn’s response to future exposure to pertussis. For example, Tdap vaccines induce pathogen specific antibodies, and those antibodies are known to be transferred from mother to the fetus in utero and to the newborn via milk. But antibodies alone have modest impact on pertussis disease, and even less effect on colonization/transmission. Maternal immune cells can also be transferred to offspring and may play a direct role in protection from disease and/or influence the developing neonatal immune system. However, some of the transferred immunity may also blunt the offspring’s response to subsequent vaccination. In this review we will summarize the protection conferred to offspring by maternal vaccination against pertussis and the likely mechanisms by which protection is transferred, identifying the many knowledge gaps that limit our most effective application of this approach. Frontiers Media S.A. 2023-07-12 /pmc/articles/PMC10374427/ /pubmed/37520565 http://dx.doi.org/10.3389/fimmu.2023.1210580 Text en Copyright © 2023 Callender and Harvill https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Callender, Maiya
Harvill, Eric T.
Maternal vaccination: shaping the neonatal response to pertussis
title Maternal vaccination: shaping the neonatal response to pertussis
title_full Maternal vaccination: shaping the neonatal response to pertussis
title_fullStr Maternal vaccination: shaping the neonatal response to pertussis
title_full_unstemmed Maternal vaccination: shaping the neonatal response to pertussis
title_short Maternal vaccination: shaping the neonatal response to pertussis
title_sort maternal vaccination: shaping the neonatal response to pertussis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374427/
https://www.ncbi.nlm.nih.gov/pubmed/37520565
http://dx.doi.org/10.3389/fimmu.2023.1210580
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