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Melatonin regulates the periodic growth of secondary hair follicles through the nuclear receptor RORα
Cashmere is the fine bottom hair produced by the secondary hair follicles of the skin. This hair is economically important. Previous studies by our research group have shown that exogenous melatonin (MT) can regulate the periodic growth of secondary hair follicles, induce the secondary development o...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374452/ https://www.ncbi.nlm.nih.gov/pubmed/37520005 http://dx.doi.org/10.3389/fvets.2023.1203302 |
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author | Lu, Zeyu Wu, Jing Wu, Jing Zhang, Tiejia Liu, Junyang Mu, Qing Terigele Wu, Zixian Zhang, Yanjun Su, Rui Liu, Zhihong Wang, Zhiying Wang, Ruijun Qi, Lv Zhao, Yanhong |
author_facet | Lu, Zeyu Wu, Jing Wu, Jing Zhang, Tiejia Liu, Junyang Mu, Qing Terigele Wu, Zixian Zhang, Yanjun Su, Rui Liu, Zhihong Wang, Zhiying Wang, Ruijun Qi, Lv Zhao, Yanhong |
author_sort | Lu, Zeyu |
collection | PubMed |
description | Cashmere is the fine bottom hair produced by the secondary hair follicles of the skin. This hair is economically important. Previous studies by our research group have shown that exogenous melatonin (MT) can regulate the periodic growth of secondary hair follicles, induce the secondary development of villi, and alter the expression of some genes related to hair follicle development. Few studies on the regulation of villus growth by MT binding receptors have been published. In this study, MT was implanted subcutaneously behind the ear of Inner Mongolia cashmere goats. RT-qPCR, in situ hybridization, Western blot analysis, immunofluorescence and RNAi techniques were used to investigate the receptors and functions of MT in regulating the development of secondary hair follicles in Inner Mongolia cashmere goats. The results showed that MT binds to the nuclear receptor RORα on dermal papilla stimulates hair follicle development and promotes villus growth. The RORα mRNA expression in the skin of Inner Mongolia cashmere goats was periodic and showed a trend of first increasing and then decreasing. The expression began to increase in February, peaked in April, and reached the lowest level in May. RORα significantly affected the mRNA expression of β-catenin gene, a key gene in hair follicle development, in the presence of MT. It will lay a solid molecular foundation for further research on the regulation mechanism between MT receptor and villus growth and development and to achieve artificial regulation of villus growth time and yield to improve the effect of villus production. |
format | Online Article Text |
id | pubmed-10374452 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103744522023-07-29 Melatonin regulates the periodic growth of secondary hair follicles through the nuclear receptor RORα Lu, Zeyu Wu, Jing Wu, Jing Zhang, Tiejia Liu, Junyang Mu, Qing Terigele Wu, Zixian Zhang, Yanjun Su, Rui Liu, Zhihong Wang, Zhiying Wang, Ruijun Qi, Lv Zhao, Yanhong Front Vet Sci Veterinary Science Cashmere is the fine bottom hair produced by the secondary hair follicles of the skin. This hair is economically important. Previous studies by our research group have shown that exogenous melatonin (MT) can regulate the periodic growth of secondary hair follicles, induce the secondary development of villi, and alter the expression of some genes related to hair follicle development. Few studies on the regulation of villus growth by MT binding receptors have been published. In this study, MT was implanted subcutaneously behind the ear of Inner Mongolia cashmere goats. RT-qPCR, in situ hybridization, Western blot analysis, immunofluorescence and RNAi techniques were used to investigate the receptors and functions of MT in regulating the development of secondary hair follicles in Inner Mongolia cashmere goats. The results showed that MT binds to the nuclear receptor RORα on dermal papilla stimulates hair follicle development and promotes villus growth. The RORα mRNA expression in the skin of Inner Mongolia cashmere goats was periodic and showed a trend of first increasing and then decreasing. The expression began to increase in February, peaked in April, and reached the lowest level in May. RORα significantly affected the mRNA expression of β-catenin gene, a key gene in hair follicle development, in the presence of MT. It will lay a solid molecular foundation for further research on the regulation mechanism between MT receptor and villus growth and development and to achieve artificial regulation of villus growth time and yield to improve the effect of villus production. Frontiers Media S.A. 2023-07-10 /pmc/articles/PMC10374452/ /pubmed/37520005 http://dx.doi.org/10.3389/fvets.2023.1203302 Text en Copyright © 2023 Lu, Wu, Wu, Zhang, Liu, Mu, Terigele, Wu, Zhang, Su, Liu, Wang, Wang, Qi and Zhao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Veterinary Science Lu, Zeyu Wu, Jing Wu, Jing Zhang, Tiejia Liu, Junyang Mu, Qing Terigele Wu, Zixian Zhang, Yanjun Su, Rui Liu, Zhihong Wang, Zhiying Wang, Ruijun Qi, Lv Zhao, Yanhong Melatonin regulates the periodic growth of secondary hair follicles through the nuclear receptor RORα |
title | Melatonin regulates the periodic growth of secondary hair follicles through the nuclear receptor RORα |
title_full | Melatonin regulates the periodic growth of secondary hair follicles through the nuclear receptor RORα |
title_fullStr | Melatonin regulates the periodic growth of secondary hair follicles through the nuclear receptor RORα |
title_full_unstemmed | Melatonin regulates the periodic growth of secondary hair follicles through the nuclear receptor RORα |
title_short | Melatonin regulates the periodic growth of secondary hair follicles through the nuclear receptor RORα |
title_sort | melatonin regulates the periodic growth of secondary hair follicles through the nuclear receptor rorα |
topic | Veterinary Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374452/ https://www.ncbi.nlm.nih.gov/pubmed/37520005 http://dx.doi.org/10.3389/fvets.2023.1203302 |
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