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Investigating microglia-neuron crosstalk by characterizing microglial contamination in human and mouse patch-seq datasets

Microglia are cells with diverse roles, including the regulation of neuronal excitability. We leveraged Patch-seq to assess the presence and effects of microglia in the local microenvironment of recorded neurons. We first quantified the amounts of microglial transcripts in three Patch-seq datasets o...

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Detalles Bibliográficos
Autores principales: Arbabi, Keon, Jiang, Yiyue, Howard, Derek, Nigam, Anukrati, Inoue, Wataru, Gonzalez-Burgos, Guillermo, Felsky, Daniel, Tripathy, Shreejoy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374462/
https://www.ncbi.nlm.nih.gov/pubmed/37520693
http://dx.doi.org/10.1016/j.isci.2023.107329