MDM2- an indispensable player in tumorigenesis

Murine double minute 2 (MDM2) is a well-recognized molecule for its oncogenic potential. Since its identification, various cancer-promoting roles of MDM2 such as growth stimulation, sustained angiogenesis, metabolic reprogramming, apoptosis evasion, metastasis, and immunosuppression have been establ...

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Detalles Bibliográficos
Autores principales: Zafar, Aasma, Khan, Muhammad Jawad, Naeem, Aisha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374471/
https://www.ncbi.nlm.nih.gov/pubmed/37314603
http://dx.doi.org/10.1007/s11033-023-08512-3
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author Zafar, Aasma
Khan, Muhammad Jawad
Naeem, Aisha
author_facet Zafar, Aasma
Khan, Muhammad Jawad
Naeem, Aisha
author_sort Zafar, Aasma
collection PubMed
description Murine double minute 2 (MDM2) is a well-recognized molecule for its oncogenic potential. Since its identification, various cancer-promoting roles of MDM2 such as growth stimulation, sustained angiogenesis, metabolic reprogramming, apoptosis evasion, metastasis, and immunosuppression have been established. Alterations in the expression levels of MDM2 occur in multiple types of cancers resulting in uncontrolled proliferation. The cellular processes are modulated by MDM2 through transcription, post-translational modifications, protein degradation, binding to cofactors, and subcellular localization. In this review, we discuss the precise role of deregulated MDM2 levels in modulating cellular functions to promote cancer growth. Moreover, we also briefly discuss the role of MDM2 in inducing resistance against anti-cancerous therapies thus limiting the benefits of cancerous treatment.
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spelling pubmed-103744712023-07-29 MDM2- an indispensable player in tumorigenesis Zafar, Aasma Khan, Muhammad Jawad Naeem, Aisha Mol Biol Rep Review Article Murine double minute 2 (MDM2) is a well-recognized molecule for its oncogenic potential. Since its identification, various cancer-promoting roles of MDM2 such as growth stimulation, sustained angiogenesis, metabolic reprogramming, apoptosis evasion, metastasis, and immunosuppression have been established. Alterations in the expression levels of MDM2 occur in multiple types of cancers resulting in uncontrolled proliferation. The cellular processes are modulated by MDM2 through transcription, post-translational modifications, protein degradation, binding to cofactors, and subcellular localization. In this review, we discuss the precise role of deregulated MDM2 levels in modulating cellular functions to promote cancer growth. Moreover, we also briefly discuss the role of MDM2 in inducing resistance against anti-cancerous therapies thus limiting the benefits of cancerous treatment. Springer Netherlands 2023-06-14 2023 /pmc/articles/PMC10374471/ /pubmed/37314603 http://dx.doi.org/10.1007/s11033-023-08512-3 Text en © The Author(s) 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Zafar, Aasma
Khan, Muhammad Jawad
Naeem, Aisha
MDM2- an indispensable player in tumorigenesis
title MDM2- an indispensable player in tumorigenesis
title_full MDM2- an indispensable player in tumorigenesis
title_fullStr MDM2- an indispensable player in tumorigenesis
title_full_unstemmed MDM2- an indispensable player in tumorigenesis
title_short MDM2- an indispensable player in tumorigenesis
title_sort mdm2- an indispensable player in tumorigenesis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374471/
https://www.ncbi.nlm.nih.gov/pubmed/37314603
http://dx.doi.org/10.1007/s11033-023-08512-3
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