An overview of arsenic trioxide-involved combined treatment algorithms for leukemia: basic concepts and clinical implications

Arsenic trioxide is a first-line treatment drug for acute promyelocytic leukemia, which is also effective for other kinds of leukemia. Its side effects, however, limit its clinical application, especially for patients with complex leukemia symptoms. Combination therapy can effectively alleviate thes...

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Autores principales: Jiang, Yanan, Shen, Xiuyun, Zhi, Fengnan, Wen, Zhengchao, Gao, Yang, Xu, Juan, Yang, Baofeng, Bai, Yunlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374529/
https://www.ncbi.nlm.nih.gov/pubmed/37500645
http://dx.doi.org/10.1038/s41420-023-01558-z
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author Jiang, Yanan
Shen, Xiuyun
Zhi, Fengnan
Wen, Zhengchao
Gao, Yang
Xu, Juan
Yang, Baofeng
Bai, Yunlong
author_facet Jiang, Yanan
Shen, Xiuyun
Zhi, Fengnan
Wen, Zhengchao
Gao, Yang
Xu, Juan
Yang, Baofeng
Bai, Yunlong
author_sort Jiang, Yanan
collection PubMed
description Arsenic trioxide is a first-line treatment drug for acute promyelocytic leukemia, which is also effective for other kinds of leukemia. Its side effects, however, limit its clinical application, especially for patients with complex leukemia symptoms. Combination therapy can effectively alleviate these problems. This review summarizes the research progress on the combination of arsenic trioxide with anticancer drugs, vitamin and vitamin analogs, plant products, and other kinds of drugs in the treatment of leukemia. Additionally, the new progress in arsenic trioxide-induced cardiotoxicity was summarized. This review aims to provide new insights for the rational clinical application of arsenic trioxide. [Image: see text]
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spelling pubmed-103745292023-07-29 An overview of arsenic trioxide-involved combined treatment algorithms for leukemia: basic concepts and clinical implications Jiang, Yanan Shen, Xiuyun Zhi, Fengnan Wen, Zhengchao Gao, Yang Xu, Juan Yang, Baofeng Bai, Yunlong Cell Death Discov Review Article Arsenic trioxide is a first-line treatment drug for acute promyelocytic leukemia, which is also effective for other kinds of leukemia. Its side effects, however, limit its clinical application, especially for patients with complex leukemia symptoms. Combination therapy can effectively alleviate these problems. This review summarizes the research progress on the combination of arsenic trioxide with anticancer drugs, vitamin and vitamin analogs, plant products, and other kinds of drugs in the treatment of leukemia. Additionally, the new progress in arsenic trioxide-induced cardiotoxicity was summarized. This review aims to provide new insights for the rational clinical application of arsenic trioxide. [Image: see text] Nature Publishing Group UK 2023-07-27 /pmc/articles/PMC10374529/ /pubmed/37500645 http://dx.doi.org/10.1038/s41420-023-01558-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Jiang, Yanan
Shen, Xiuyun
Zhi, Fengnan
Wen, Zhengchao
Gao, Yang
Xu, Juan
Yang, Baofeng
Bai, Yunlong
An overview of arsenic trioxide-involved combined treatment algorithms for leukemia: basic concepts and clinical implications
title An overview of arsenic trioxide-involved combined treatment algorithms for leukemia: basic concepts and clinical implications
title_full An overview of arsenic trioxide-involved combined treatment algorithms for leukemia: basic concepts and clinical implications
title_fullStr An overview of arsenic trioxide-involved combined treatment algorithms for leukemia: basic concepts and clinical implications
title_full_unstemmed An overview of arsenic trioxide-involved combined treatment algorithms for leukemia: basic concepts and clinical implications
title_short An overview of arsenic trioxide-involved combined treatment algorithms for leukemia: basic concepts and clinical implications
title_sort overview of arsenic trioxide-involved combined treatment algorithms for leukemia: basic concepts and clinical implications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374529/
https://www.ncbi.nlm.nih.gov/pubmed/37500645
http://dx.doi.org/10.1038/s41420-023-01558-z
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