A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity

The inhibition of protein tyrosine phosphatases 1B (PTP1B) and N2 (PTPN2) has emerged as an exciting approach for bolstering T cell anti-tumor immunity. ABBV-CLS-484 is a PTP1B/PTPN2 inhibitor in clinical trials for solid tumors. Here we have explored the therapeutic potential of a related small-mol...

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Detalles Bibliográficos
Autores principales: Liang, Shuwei, Tran, Eric, Du, Xin, Dong, Jiajun, Sudholz, Harrison, Chen, Hao, Qu, Zihan, Huntington, Nicholas D., Babon, Jeffrey J., Kershaw, Nadia J., Zhang, Zhong-Yin, Baell, Jonathan B., Wiede, Florian, Tiganis, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374545/
https://www.ncbi.nlm.nih.gov/pubmed/37500611
http://dx.doi.org/10.1038/s41467-023-40170-8

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