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A new glance at autophagolysosomal-dependent or -independent function of transcriptional factor EB in human cancer

Autophagy-lysosome system plays a variety of roles in human cancers. In addition to being implicated in metabolism, it is also involved in tumor immunity, remodeling the tumor microenvironment, vascular proliferation, and promoting tumor progression and metastasis. Transcriptional factor EB (TFEB) i...

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Autores principales: Wang, Ting, Qin, Yi, Ye, Zeng, Jing, De-sheng, Fan, Gui-xiong, Liu, Meng-qi, Zhuo, Qi-feng, Ji, Shun-rong, Chen, Xue-min, Yu, Xian-jun, Xu, Xiao-wu, Li, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374590/
https://www.ncbi.nlm.nih.gov/pubmed/37012494
http://dx.doi.org/10.1038/s41401-023-01078-7
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author Wang, Ting
Qin, Yi
Ye, Zeng
Jing, De-sheng
Fan, Gui-xiong
Liu, Meng-qi
Zhuo, Qi-feng
Ji, Shun-rong
Chen, Xue-min
Yu, Xian-jun
Xu, Xiao-wu
Li, Zheng
author_facet Wang, Ting
Qin, Yi
Ye, Zeng
Jing, De-sheng
Fan, Gui-xiong
Liu, Meng-qi
Zhuo, Qi-feng
Ji, Shun-rong
Chen, Xue-min
Yu, Xian-jun
Xu, Xiao-wu
Li, Zheng
author_sort Wang, Ting
collection PubMed
description Autophagy-lysosome system plays a variety of roles in human cancers. In addition to being implicated in metabolism, it is also involved in tumor immunity, remodeling the tumor microenvironment, vascular proliferation, and promoting tumor progression and metastasis. Transcriptional factor EB (TFEB) is a major regulator of the autophagy-lysosomal system. With the in-depth studies on TFEB, researchers have found that it promotes various cancer phenotypes by regulating the autophagolysosomal system, and even in an autophagy-independent way. In this review, we summarize the recent findings about TFEB in various types of cancer (melanoma, pancreatic ductal adenocarcinoma, renal cell carcinoma, colorectal cancer, breast cancer, prostate cancer, ovarian cancer and lung cancer), and shed some light on the mechanisms by which it may serve as a potential target for cancer treatment.
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spelling pubmed-103745902023-07-29 A new glance at autophagolysosomal-dependent or -independent function of transcriptional factor EB in human cancer Wang, Ting Qin, Yi Ye, Zeng Jing, De-sheng Fan, Gui-xiong Liu, Meng-qi Zhuo, Qi-feng Ji, Shun-rong Chen, Xue-min Yu, Xian-jun Xu, Xiao-wu Li, Zheng Acta Pharmacol Sin Review Article Autophagy-lysosome system plays a variety of roles in human cancers. In addition to being implicated in metabolism, it is also involved in tumor immunity, remodeling the tumor microenvironment, vascular proliferation, and promoting tumor progression and metastasis. Transcriptional factor EB (TFEB) is a major regulator of the autophagy-lysosomal system. With the in-depth studies on TFEB, researchers have found that it promotes various cancer phenotypes by regulating the autophagolysosomal system, and even in an autophagy-independent way. In this review, we summarize the recent findings about TFEB in various types of cancer (melanoma, pancreatic ductal adenocarcinoma, renal cell carcinoma, colorectal cancer, breast cancer, prostate cancer, ovarian cancer and lung cancer), and shed some light on the mechanisms by which it may serve as a potential target for cancer treatment. Springer Nature Singapore 2023-04-03 2023-08 /pmc/articles/PMC10374590/ /pubmed/37012494 http://dx.doi.org/10.1038/s41401-023-01078-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Wang, Ting
Qin, Yi
Ye, Zeng
Jing, De-sheng
Fan, Gui-xiong
Liu, Meng-qi
Zhuo, Qi-feng
Ji, Shun-rong
Chen, Xue-min
Yu, Xian-jun
Xu, Xiao-wu
Li, Zheng
A new glance at autophagolysosomal-dependent or -independent function of transcriptional factor EB in human cancer
title A new glance at autophagolysosomal-dependent or -independent function of transcriptional factor EB in human cancer
title_full A new glance at autophagolysosomal-dependent or -independent function of transcriptional factor EB in human cancer
title_fullStr A new glance at autophagolysosomal-dependent or -independent function of transcriptional factor EB in human cancer
title_full_unstemmed A new glance at autophagolysosomal-dependent or -independent function of transcriptional factor EB in human cancer
title_short A new glance at autophagolysosomal-dependent or -independent function of transcriptional factor EB in human cancer
title_sort new glance at autophagolysosomal-dependent or -independent function of transcriptional factor eb in human cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374590/
https://www.ncbi.nlm.nih.gov/pubmed/37012494
http://dx.doi.org/10.1038/s41401-023-01078-7
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