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Nonclassical mechanisms to irreversibly suppress β-hematin crystal growth

Hematin crystallization is an essential element of heme detoxification of malaria parasites and its inhibition by antimalarial drugs is a common treatment avenue. We demonstrate at biomimetic conditions in vitro irreversible inhibition of hematin crystal growth due to distinct cooperative mechanisms...

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Detalles Bibliográficos
Autores principales:	Ma, Wenchuan, Balta, Victoria A., Pan, Weichun, Rimer, Jeffrey D., Sullivan, David J., Vekilov, Peter G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374632/ https://www.ncbi.nlm.nih.gov/pubmed/37500754 http://dx.doi.org/10.1038/s42003-023-05046-z

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