The role of Pcdh10 in neurological disease and cancer

BACKGROUND: Protocadherin 10 (PCDH 10), a member of the superfamily of protocadherins, is a Ca2(+)-dependent homophilic cell-cell adhesion molecule expressed on the surface of cell membranes. Protocadherin 10 plays a critical role in the central nervous system including in cell adhesion, formation a...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhen, Yilan, Pavez, Macarena, Li, Xinying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374755/
https://www.ncbi.nlm.nih.gov/pubmed/37058252
http://dx.doi.org/10.1007/s00432-023-04743-w
_version_ 1785078845144039424
author Zhen, Yilan
Pavez, Macarena
Li, Xinying
author_facet Zhen, Yilan
Pavez, Macarena
Li, Xinying
author_sort Zhen, Yilan
collection PubMed
description BACKGROUND: Protocadherin 10 (PCDH 10), a member of the superfamily of protocadherins, is a Ca2(+)-dependent homophilic cell-cell adhesion molecule expressed on the surface of cell membranes. Protocadherin 10 plays a critical role in the central nervous system including in cell adhesion, formation and maintenance of neural circuits and synapses, regulation of actin assembly, cognitive function and tumor suppression. Additionally, Pcdh10 can serve as a non-invasive diagnostic and prognostic indicator for various cancers. METHODS: This paper collects and reviews relevant literature in Pubmed. CONCLUSION: This review describes the latest research understanding the role of Pcdh10 in neurological disease and human cancer, highlighting the importance of scrutinizing its properties for the development of targeted therapies and identifying a need for further research to explore Pcdh10 functions in other pathways, cell types and human pathologies.
format Online
Article
Text
id pubmed-10374755
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-103747552023-07-29 The role of Pcdh10 in neurological disease and cancer Zhen, Yilan Pavez, Macarena Li, Xinying J Cancer Res Clin Oncol Review BACKGROUND: Protocadherin 10 (PCDH 10), a member of the superfamily of protocadherins, is a Ca2(+)-dependent homophilic cell-cell adhesion molecule expressed on the surface of cell membranes. Protocadherin 10 plays a critical role in the central nervous system including in cell adhesion, formation and maintenance of neural circuits and synapses, regulation of actin assembly, cognitive function and tumor suppression. Additionally, Pcdh10 can serve as a non-invasive diagnostic and prognostic indicator for various cancers. METHODS: This paper collects and reviews relevant literature in Pubmed. CONCLUSION: This review describes the latest research understanding the role of Pcdh10 in neurological disease and human cancer, highlighting the importance of scrutinizing its properties for the development of targeted therapies and identifying a need for further research to explore Pcdh10 functions in other pathways, cell types and human pathologies. Springer Berlin Heidelberg 2023-04-14 2023 /pmc/articles/PMC10374755/ /pubmed/37058252 http://dx.doi.org/10.1007/s00432-023-04743-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Zhen, Yilan
Pavez, Macarena
Li, Xinying
The role of Pcdh10 in neurological disease and cancer
title The role of Pcdh10 in neurological disease and cancer
title_full The role of Pcdh10 in neurological disease and cancer
title_fullStr The role of Pcdh10 in neurological disease and cancer
title_full_unstemmed The role of Pcdh10 in neurological disease and cancer
title_short The role of Pcdh10 in neurological disease and cancer
title_sort role of pcdh10 in neurological disease and cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374755/
https://www.ncbi.nlm.nih.gov/pubmed/37058252
http://dx.doi.org/10.1007/s00432-023-04743-w
work_keys_str_mv AT zhenyilan theroleofpcdh10inneurologicaldiseaseandcancer
AT pavezmacarena theroleofpcdh10inneurologicaldiseaseandcancer
AT lixinying theroleofpcdh10inneurologicaldiseaseandcancer
AT zhenyilan roleofpcdh10inneurologicaldiseaseandcancer
AT pavezmacarena roleofpcdh10inneurologicaldiseaseandcancer
AT lixinying roleofpcdh10inneurologicaldiseaseandcancer

Ejemplares similares