The role of GLUT2 in glucose metabolism in multiple organs and tissues

The glucose transporter family has an important role in the initial stage of glucose metabolism; Glucose transporters 2 (GLUTs, encoded by the solute carrier family 2, SLC2A genes) is the major glucose transporter in β-cells of pancreatic islets and hepatocytes but is also expressed in the small int...

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Autores principales: Sun, Bo, Chen, Hui, Xue, Jisu, Li, Peiwu, Fu, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374759/
https://www.ncbi.nlm.nih.gov/pubmed/37358764
http://dx.doi.org/10.1007/s11033-023-08535-w
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author Sun, Bo
Chen, Hui
Xue, Jisu
Li, Peiwu
Fu, Xu
author_facet Sun, Bo
Chen, Hui
Xue, Jisu
Li, Peiwu
Fu, Xu
author_sort Sun, Bo
collection PubMed
description The glucose transporter family has an important role in the initial stage of glucose metabolism; Glucose transporters 2 (GLUTs, encoded by the solute carrier family 2, SLC2A genes) is the major glucose transporter in β-cells of pancreatic islets and hepatocytes but is also expressed in the small intestine, kidneys, and central nervous system; GLUT2 has a relatively low affinity to glucose. Under physiological conditions, GLUT2 transports glucose into cells and allows the glucose concentration to reach balance on the bilateral sides of the cellular membrane; Variation of GLUT2 is associated with various endocrine and metabolic disorders; In this study, we discussed the role of GLUT2 in participating in glucose metabolism and regulation in multiple organs and tissues and its effects on maintaining glucose homeostasis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11033-023-08535-w.
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spelling pubmed-103747592023-07-29 The role of GLUT2 in glucose metabolism in multiple organs and tissues Sun, Bo Chen, Hui Xue, Jisu Li, Peiwu Fu, Xu Mol Biol Rep Review The glucose transporter family has an important role in the initial stage of glucose metabolism; Glucose transporters 2 (GLUTs, encoded by the solute carrier family 2, SLC2A genes) is the major glucose transporter in β-cells of pancreatic islets and hepatocytes but is also expressed in the small intestine, kidneys, and central nervous system; GLUT2 has a relatively low affinity to glucose. Under physiological conditions, GLUT2 transports glucose into cells and allows the glucose concentration to reach balance on the bilateral sides of the cellular membrane; Variation of GLUT2 is associated with various endocrine and metabolic disorders; In this study, we discussed the role of GLUT2 in participating in glucose metabolism and regulation in multiple organs and tissues and its effects on maintaining glucose homeostasis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11033-023-08535-w. Springer Netherlands 2023-06-26 2023 /pmc/articles/PMC10374759/ /pubmed/37358764 http://dx.doi.org/10.1007/s11033-023-08535-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Sun, Bo
Chen, Hui
Xue, Jisu
Li, Peiwu
Fu, Xu
The role of GLUT2 in glucose metabolism in multiple organs and tissues
title The role of GLUT2 in glucose metabolism in multiple organs and tissues
title_full The role of GLUT2 in glucose metabolism in multiple organs and tissues
title_fullStr The role of GLUT2 in glucose metabolism in multiple organs and tissues
title_full_unstemmed The role of GLUT2 in glucose metabolism in multiple organs and tissues
title_short The role of GLUT2 in glucose metabolism in multiple organs and tissues
title_sort role of glut2 in glucose metabolism in multiple organs and tissues
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374759/
https://www.ncbi.nlm.nih.gov/pubmed/37358764
http://dx.doi.org/10.1007/s11033-023-08535-w
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