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Female breast cancer subtypes in the Romagna Unit of the Emilia-Romagna cancer registry, and estimated incident cases by subtypes and age in Italy in 2020

PURPOSE: The aim of this study was to estimate the Italian burden of incident breast cancer (BC) by subtypes, according to the distribution of hormonal receptor (HR) status and expression of human epidermal growth factor 2 (HER2). METHODS: Female breast cancers incidence in the Romagna Unit of the E...

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Autores principales: Crocetti, Emanuele, Ravaioli, Alessandra, Giuliani, Orietta, Bucchi, Lauro, Vattiato, Rosa, Mancini, Silvia, Zamagni, Federica, Vitali, Benedetta, Balducci, Chiara, Baldacchini, Flavia, Falcini, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374783/
https://www.ncbi.nlm.nih.gov/pubmed/36922443
http://dx.doi.org/10.1007/s00432-023-04593-6
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author Crocetti, Emanuele
Ravaioli, Alessandra
Giuliani, Orietta
Bucchi, Lauro
Vattiato, Rosa
Mancini, Silvia
Zamagni, Federica
Vitali, Benedetta
Balducci, Chiara
Baldacchini, Flavia
Falcini, Fabio
author_facet Crocetti, Emanuele
Ravaioli, Alessandra
Giuliani, Orietta
Bucchi, Lauro
Vattiato, Rosa
Mancini, Silvia
Zamagni, Federica
Vitali, Benedetta
Balducci, Chiara
Baldacchini, Flavia
Falcini, Fabio
author_sort Crocetti, Emanuele
collection PubMed
description PURPOSE: The aim of this study was to estimate the Italian burden of incident breast cancer (BC) by subtypes, according to the distribution of hormonal receptor (HR) status and expression of human epidermal growth factor 2 (HER2). METHODS: Female breast cancers incidence in the Romagna Unit of the Emilia-Romagna registry (n. 10,711) were grouped into: HR+ /HER2–, HR+ /HER2+ , HR–/HER2+ , HR–/HER2– and missing, and by age: < 50, 50–69 and 70+ years. Data were compared with other published Italian population-bases series before using them for national estimates. We used national and regional numbers of expected breast cancers published by the Italian network of cancer registries considering the age- and geographic-specific variation of the Italian population. RESULTS: Overall, 70.7% of incident BC cases are expected to be HR+ /HER2-, 8.5% HR+ /HER2+ , 7.5% HR-/HER2-, 4.1% HR-/HER2+ and 9.3% missing. The global ranking is similar across age-groups but with age-specific differences. The proportion of missing was around 3-times lower than in the other Italian published population-based series and similar to the SEER one. In Italy, are estimated 38,841 HR+ /HER2- breast cancer cases, 4665 HR+ /HER2+ , 4098 HR-/HER2-, 2281 HR-/HER2+ , and 5092 not specified. Numbers by age-group were provided. CONCLUSIONS: The present estimates relied on high-quality population-based data and provide a clinically relevant information on the burden of breast cancer subtypes. These data will support the planning of therapy needs for oncologists, decision-makers, and all other stakeholders.
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spelling pubmed-103747832023-07-29 Female breast cancer subtypes in the Romagna Unit of the Emilia-Romagna cancer registry, and estimated incident cases by subtypes and age in Italy in 2020 Crocetti, Emanuele Ravaioli, Alessandra Giuliani, Orietta Bucchi, Lauro Vattiato, Rosa Mancini, Silvia Zamagni, Federica Vitali, Benedetta Balducci, Chiara Baldacchini, Flavia Falcini, Fabio J Cancer Res Clin Oncol Research PURPOSE: The aim of this study was to estimate the Italian burden of incident breast cancer (BC) by subtypes, according to the distribution of hormonal receptor (HR) status and expression of human epidermal growth factor 2 (HER2). METHODS: Female breast cancers incidence in the Romagna Unit of the Emilia-Romagna registry (n. 10,711) were grouped into: HR+ /HER2–, HR+ /HER2+ , HR–/HER2+ , HR–/HER2– and missing, and by age: < 50, 50–69 and 70+ years. Data were compared with other published Italian population-bases series before using them for national estimates. We used national and regional numbers of expected breast cancers published by the Italian network of cancer registries considering the age- and geographic-specific variation of the Italian population. RESULTS: Overall, 70.7% of incident BC cases are expected to be HR+ /HER2-, 8.5% HR+ /HER2+ , 7.5% HR-/HER2-, 4.1% HR-/HER2+ and 9.3% missing. The global ranking is similar across age-groups but with age-specific differences. The proportion of missing was around 3-times lower than in the other Italian published population-based series and similar to the SEER one. In Italy, are estimated 38,841 HR+ /HER2- breast cancer cases, 4665 HR+ /HER2+ , 4098 HR-/HER2-, 2281 HR-/HER2+ , and 5092 not specified. Numbers by age-group were provided. CONCLUSIONS: The present estimates relied on high-quality population-based data and provide a clinically relevant information on the burden of breast cancer subtypes. These data will support the planning of therapy needs for oncologists, decision-makers, and all other stakeholders. Springer Berlin Heidelberg 2023-03-15 2023 /pmc/articles/PMC10374783/ /pubmed/36922443 http://dx.doi.org/10.1007/s00432-023-04593-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Crocetti, Emanuele
Ravaioli, Alessandra
Giuliani, Orietta
Bucchi, Lauro
Vattiato, Rosa
Mancini, Silvia
Zamagni, Federica
Vitali, Benedetta
Balducci, Chiara
Baldacchini, Flavia
Falcini, Fabio
Female breast cancer subtypes in the Romagna Unit of the Emilia-Romagna cancer registry, and estimated incident cases by subtypes and age in Italy in 2020
title Female breast cancer subtypes in the Romagna Unit of the Emilia-Romagna cancer registry, and estimated incident cases by subtypes and age in Italy in 2020
title_full Female breast cancer subtypes in the Romagna Unit of the Emilia-Romagna cancer registry, and estimated incident cases by subtypes and age in Italy in 2020
title_fullStr Female breast cancer subtypes in the Romagna Unit of the Emilia-Romagna cancer registry, and estimated incident cases by subtypes and age in Italy in 2020
title_full_unstemmed Female breast cancer subtypes in the Romagna Unit of the Emilia-Romagna cancer registry, and estimated incident cases by subtypes and age in Italy in 2020
title_short Female breast cancer subtypes in the Romagna Unit of the Emilia-Romagna cancer registry, and estimated incident cases by subtypes and age in Italy in 2020
title_sort female breast cancer subtypes in the romagna unit of the emilia-romagna cancer registry, and estimated incident cases by subtypes and age in italy in 2020
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374783/
https://www.ncbi.nlm.nih.gov/pubmed/36922443
http://dx.doi.org/10.1007/s00432-023-04593-6
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