Cargando…

Tumor suppressor miR-218 directly targets epidermal growth factor receptor (EGFR) expression in triple-negative breast cancer, sensitizing cells to irradiation

PURPOSE: MicroRNA-218 (miR-218) is a key regulator of numerous processes relevant to tumor progression. In the present study, we aimed to characterize the relationship between miR-218 and the Epidermal Growth Factor Receptor (EGFR) as well as to understand downstream effects in triple-negative breas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wischmann, Franz-Josef, Troschel, Fabian M., Frankenberg, Maj, Kemper, Björn, Vijaya Kumar, Archana, Sicking, Mark, Ibrahim, Sherif Abdelaziz, Kiesel, Ludwig, Götte, Martin, Eich, Hans Theodor, Greve, Burkhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374822/ https://www.ncbi.nlm.nih.gov/pubmed/37088795 http://dx.doi.org/10.1007/s00432-023-04750-x

Ejemplares similares

Knockdown of Musashi RNA Binding Proteins Decreases Radioresistance but Enhances Cell Motility and Invasion in Triple-Negative Breast Cancer
por: Troschel, Fabian M., et al.
Publicado: (2020)

The Musashi RNA-binding proteins in female cancers: insights on molecular mechanisms and therapeutic relevance
por: Sicking, Mark, et al.
Publicado: (2023)

Dual Knockdown of Musashi RNA-Binding Proteins MSI-1 and MSI-2 Attenuates Putative Cancer Stem Cell Characteristics and Therapy Resistance in Ovarian Cancer Cells
por: Löblein, Maria T., et al.
Publicado: (2021)

Knockdown of the prognostic cancer stem cell marker Musashi-1 decreases radio-resistance while enhancing apoptosis in hormone receptor-positive breast cancer cells via p21(WAF1/CIP1)
por: Troschel, Fabian M., et al.
Publicado: (2021)

Syndecan-1 (CD138) Modulates Triple-Negative Breast Cancer Stem Cell Properties via Regulation of LRP-6 and IL-6-Mediated STAT3 Signaling
por: Ibrahim, Sherif A., et al.
Publicado: (2013)

Knockdown of the stem cell marker Musashi-1 inhibits endometrial cancer growth and sensitizes cells to radiation
por: Falke, Isabel, et al.
Publicado: (2022)

Differential Impact of Membrane-Bound and Soluble Forms of the Prognostic Marker Syndecan-1 on the Invasiveness, Migration, Apoptosis, and Proliferation of Cervical Cancer Cells
por: Hilgers, Katharina, et al.
Publicado: (2022)

HS2ST1‐dependent signaling pathways determine breast cancer cell viability, matrix interactions, and invasive behavior
por: Vijaya Kumar, Archana, et al.
Publicado: (2020)

Syndecan-1 Promotes Angiogenesis in Triple-Negative Breast Cancer through the Prognostically Relevant Tissue Factor Pathway and Additional Angiogenic Routes
por: Nassar, Eyyad, et al.
Publicado: (2021)

The Heparan Sulfate Sulfotransferases HS2ST1 and HS3ST2 Are Novel Regulators of Breast Cancer Stem-Cell Properties
por: Teixeira, Felipe C. O. B., et al.
Publicado: (2020)

Syndecan-1 is a novel molecular marker for triple negative inflammatory breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways
por: Ibrahim, Sherif Abdelaziz, et al.
Publicado: (2017)

The Cell Surface Heparan Sulfate Proteoglycan Syndecan-3 Promotes Ovarian Cancer Pathogenesis
por: Hillemeyer, Lara, et al.
Publicado: (2022)

miR-218 functions as a tumor suppressor gene in cervical cancer
por: Liu, Zhen, et al.
Publicado: (2020)

Characterization and dynamics of the soluble immunological microenvironment in melanoma patients undergoing radiotherapy
por: Oertel, Michael, et al.
Publicado: (2022)

MiR-218-5p/EGFR Signaling in Arsenic-Induced Carcinogenesis
por: Islam, Ranakul, et al.
Publicado: (2023)

Digital Holographic Microscopy for Label-Free Detection of Leukocyte Alternations Associated with Perioperative Inflammation after Cardiac Surgery
por: Steike, David Rene, et al.
Publicado: (2022)

The Role of Neuroaxis Irradiation in the Treatment of Intraspinal Ewing Sarcoma: A Review and Meta-Analysis
por: Troschel, Fabian M., et al.
Publicado: (2022)

Influence of secreted frizzled receptor protein 1 (SFRP1) on neoadjuvant chemotherapy in triple negative breast cancer does not rely on WNT signaling
por: Bernemann, Christof, et al.
Publicado: (2014)

Collagen I triggers directional migration, invasion and matrix remodeling of stroma cells in a 3D spheroid model of endometriosis
por: Stejskalová, Anna, et al.
Publicado: (2021)

Induction of heparanase via IL-10 correlates with a high infiltration of CD163+ M2-type tumor-associated macrophages in inflammatory breast carcinomas
por: El-Nadi, Mennatullah, et al.
Publicado: (2020)

S218. INSIGHT AND SUBJECTIVITY
por: Monserrat, Clara, et al.
Publicado: (2018)

Impact of Musashi-1 and Musashi-2 Double Knockdown on Notch Signaling and the Pathogenesis of Endometriosis
por: Strauß, Theresa, et al.
Publicado: (2022)

Small extracellular vesicle-encapsulated miR-181b-5p, miR-222-3p and let-7a-5p: Next generation plasma biopsy-based diagnostic biomarkers for inflammatory breast cancer
por: Ahmed, Sarah Hamdy, et al.
Publicado: (2021)

Editorial: Cancer stem cells as attractive targets for breast cancer therapy
por: Ibrahim, Sherif Abdelaziz, et al.
Publicado: (2023)

Fine structure in the α decay of At218
por: Cubiss, J. G., et al.
Publicado: (2019)

High-spin states of $^{218}$Th
por: O'Donnell, D, et al.
Publicado: (2020)

Health Tract, No. 218: Digestibility of Food
Publicado: (1864)

Health Tract, No. 218: Digestibility of Food
Publicado: (1865)

An expression signature of syndecan-1 (CD138), E-cadherin and c-met is associated with factors of angiogenesis and lymphangiogenesis in ductal breast carcinoma in situ
por: Götte, Martin, et al.
Publicado: (2007)

The Tissue Factor Pathway in Cancer: Overview and Role of Heparan Sulfate Proteoglycans
por: Hassan, Nourhan, et al.
Publicado: (2023)

The epidermal growth factor receptor (EGFR) contributes to efficient entry of influenza A viruses into host cells
por: Eierhoff, T, et al.
Publicado: (2009)

Expression of the epidermal growth factor receptor (EGFR) and the phosphorylated EGFR in invasive breast carcinomas
por: Magkou, Christina, et al.
Publicado: (2008)

Safety and Success of Repeat Lung Needle Biopsies in Patients with Epidermal Growth Factor Receptor‐Mutant Lung Cancer
por: Fintelmann, Florian J., et al.
Publicado: (2019)

The Epidermal Growth Factor Receptor (EGFR) Promotes Uptake of Influenza A Viruses (IAV) into Host Cells
por: Eierhoff, Thorsten, et al.
Publicado: (2010)

miR-142-3p Reduces the Size, Migration, and Contractility of Endometrial and Endometriotic Stromal Cells by Targeting Integrin- and Rho GTPase-Related Pathways That Regulate Cytoskeletal Function
por: Börschel, Christin S., et al.
Publicado: (2020)

MicroRNA-218 functions as a tumor suppressor in lung cancer by targeting IL-6/STAT3 and negatively correlates with poor prognosis
por: Yang, Yan, et al.
Publicado: (2017)

New isomeric states of $^{218}$Fr and $^{214}$At
por: Ewan, G T, et al.
Publicado: (1982)

Emergence of Extensively Drug-Resistant ST170 Citrobacter portucalensis with Plasmids pK218-KPC, pK218-NDM, and pK218-SHV from a Tertiary Hospital, China
por: Luo, Xinhua, et al.
Publicado: (2022)

microRNA miR-142-3p Inhibits Breast Cancer Cell Invasiveness by Synchronous Targeting of WASL, Integrin Alpha V, and Additional Cytoskeletal Elements
por: Schwickert, Alexander, et al.
Publicado: (2015)

Quality of Life in Brain Tumor Patients and Their Relatives Heavily Depends on Social Support Factors during the COVID-19 Pandemic
por: Troschel, Fabian M., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_q857qtem2qb0ljlahgnr5i5025