Cargando…

Splenic SUMO1 controls systemic inflammation in experimental sepsis

INTRODUCTION: The recent discovery of TAK981(Subasumstat), the first-in-class selective inhibitor of SUMOylation, enables new immune treatments. TAK981 is already in clinical trials to potentiate immunotherapy in metastatic tumors and hematologic malignancies. Cancer patients have more than ten time...

Descripción completa

Detalles Bibliográficos
Autores principales:	Youssef, Ayman, Mohammed, Bilal Khan, Prasad, Abhishek, del Aguila, Angela, Bassi, Gabriel, Yang, Wei, Ulloa, Luis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374847/ https://www.ncbi.nlm.nih.gov/pubmed/37520526 http://dx.doi.org/10.3389/fimmu.2023.1200939

Ejemplares similares

Dopaminergic Control of Inflammation and Glycemia in Sepsis and Diabetes
por: Feketeova, Eleonora, et al.
Publicado: (2018)

Experimental Stroke Differentially Affects Discrete Subpopulations of Splenic Macrophages
por: McCulloch, Laura, et al.
Publicado: (2018)

Splenic Nerve Neuromodulation Reduces Inflammation and Promotes Resolution in Chronically Implanted Pigs
por: Sokal, David M., et al.
Publicado: (2021)

The Yin and Yang of Tyrosine Kinase Inhibition During Experimental Polymicrobial Sepsis
por: Gonçalves-de-Albuquerque, Cassiano Felippe, et al.
Publicado: (2018)

Novel Insights for Systemic Inflammation in Sepsis and Hemorrhage
por: Cai, Bolin, et al.
Publicado: (2010)

Platelets in Sepsis: An Update on Experimental Models and Clinical Data
por: Assinger, Alice, et al.
Publicado: (2019)

Splenic Transcriptional Responses in Severe Visceral Leishmaniasis: Impaired Leukocyte Chemotaxis and Cell Cycle Arrest
por: de Melo, Caroline Vilas Boas, et al.
Publicado: (2021)

Forebrain Cholinergic Dysfunction and Systemic and Brain Inflammation in Murine Sepsis Survivors
por: Zaghloul, Nahla, et al.
Publicado: (2017)

Sepsis Inflammation Impairs the Generation of Functional Dendritic Cells by Targeting Their Progenitors
por: Lu, Jie, et al.
Publicado: (2021)

HIVEP1 Is a Negative Regulator of NF-κB That Inhibits Systemic Inflammation in Sepsis
por: Matsumoto, Hisatake, et al.
Publicado: (2021)

Mucins in Intestinal Mucosal Defense and Inflammation: Learning From Clinical and Experimental Studies
por: Grondin, Jensine A., et al.
Publicado: (2020)

TRIM59 Protects Mice From Sepsis by Regulating Inflammation and Phagocytosis in Macrophages
por: Jin, Zheng, et al.
Publicado: (2020)

LPIN1 Is a Regulatory Factor Associated With Immune Response and Inflammation in Sepsis
por: Dai, Wei, et al.
Publicado: (2022)

ICOS-Fc as innovative immunomodulatory approach to counteract inflammation and organ injury in sepsis
por: Alves, Gustavo Ferreira, et al.
Publicado: (2022)

Human Alveolar and Splenic Macrophage Populations Display a Distinct Transcriptomic Response to Infection With Mycobacterium tuberculosis
por: Lavalett, Lelia, et al.
Publicado: (2020)

Activation of Neutrophil Granulocytes by Platelet-Activating Factor Is Impaired During Experimental Sepsis
por: Hug, Stefan, et al.
Publicado: (2021)

αDβ2 as a novel target of experimental polymicrobial sepsis
por: Koutsogiannaki, Sophia, et al.
Publicado: (2022)

Ferritin Light Chain Confers Protection Against Sepsis-Induced Inflammation and Organ Injury
por: Zarjou, Abolfazl, et al.
Publicado: (2019)

Biomaterial-Driven Immunomodulation: Cell Biology-Based Strategies to Mitigate Severe Inflammation and Sepsis
por: Lasola, Jackline Joy Martín, et al.
Publicado: (2020)

Photoactivated adenylyl cyclases attenuate sepsis-induced cardiomyopathy by suppressing macrophage-mediated inflammation
por: Xia, Guofang, et al.
Publicado: (2022)

SHANK3 in vagal sensory neurons regulates body temperature, systemic inflammation, and sepsis
por: Zhang, Linlin, et al.
Publicado: (2023)

Gelsevirine is a novel STING-specific inhibitor and mitigates STING-related inflammation in sepsis
por: Chen, Yuhong, et al.
Publicado: (2023)

Splenic Macrophage Subsets and Their Function during Blood-Borne Infections
por: Borges da Silva, Henrique, et al.
Publicado: (2015)

Identification and experimental validation of mitochondria-related genes biomarkers associated with immune infiltration for sepsis
por: Shu, Qi, et al.
Publicado: (2023)

Identification of biomarkers related to sepsis diagnosis based on bioinformatics and machine learning and experimental verification
por: Wang, Qianfei, et al.
Publicado: (2023)

Total Chemical Synthesis of SUMO and SUMO‐Based Probes for Profiling the Activity of SUMO‐Specific Proteases
por: Mulder, Monique P. C., et al.
Publicado: (2018)

Development of Two Distinct Dendritic-Like APCs in the Context of Splenic Stroma
por: Periasamy, Pravin, et al.
Publicado: (2013)

DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages
por: Lao, Yimin, et al.
Publicado: (2018)

Sodium Thiosulfate Improves Intestinal and Hepatic Microcirculation Without Affecting Mitochondrial Function in Experimental Sepsis
por: Schulz, Jan, et al.
Publicado: (2021)

Splenic schooling dampens inflammation
por: Van Epps, Heather L.
Publicado: (2006)

Natural IgM and TLR Agonists Switch Murine Splenic Pan-B to “Regulatory” Cells That Suppress Ischemia-Induced Innate Inflammation via Regulating NKT-1 Cells
por: Lobo, Peter I., et al.
Publicado: (2017)

Siglec-G Deficiency Ameliorates Hyper-Inflammation and Immune Collapse in Sepsis via Regulating Src Activation
por: Li, Wenqian, et al.
Publicado: (2019)

The Transcription Factor FRA-1/AP-1 Controls Lipocalin-2 Expression and Inflammation in Sepsis Model
por: Cao, Shan, et al.
Publicado: (2021)

Characterization of Renal Injury and Inflammation in an Experimental Model of Intravascular Hemolysis
por: Merle, Nicolas S., et al.
Publicado: (2018)

Cross-Presentation of Cell-Associated Antigens by Mouse Splenic Dendritic Cell Populations
por: Thacker, Robert I., et al.
Publicado: (2012)

Sumo-dependent substrate targeting of the SUMO protease Ulp1
por: Elmore, Zachary C, et al.
Publicado: (2011)

Identification of proximal SUMO-dependent interactors using SUMO-ID
por: Barroso-Gomila, Orhi, et al.
Publicado: (2021)

Pulmonary Innate Immune Response Determines the Outcome of Inflammation During Pneumonia and Sepsis-Associated Acute Lung Injury
por: Kumar, Vijay
Publicado: (2020)

Intracellular S100A9 Promotes Myeloid-Derived Suppressor Cells during Late Sepsis
por: Dai, Jun, et al.
Publicado: (2017)

Ghrelin as an Anti-Sepsis Peptide: Review
por: Mathur, Nimisha, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_2q10orcdo3vtgrvnkg7aiipo9j