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Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cells
The goal of this paper was to look into the anti-tumor mechanism of Non-Steroidal Anti-Inflammatory Drug (NSAID)-conjugated SN-38 Prodrug in A549 lung cancer cells. We found that Indomethacine–SN–38 (IndoSN-38) and Naproxen–SN–38(NaproSN-38) as a theranostic prodrug targeting cyclooxygenase-2(COX-2)...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374863/ https://www.ncbi.nlm.nih.gov/pubmed/37521373 http://dx.doi.org/10.1016/j.bbrep.2023.101517 |
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author | Kwon, Hae–Won An, Jusung Kim, Jong Seung Kang, In-Cheol |
author_facet | Kwon, Hae–Won An, Jusung Kim, Jong Seung Kang, In-Cheol |
author_sort | Kwon, Hae–Won |
collection | PubMed |
description | The goal of this paper was to look into the anti-tumor mechanism of Non-Steroidal Anti-Inflammatory Drug (NSAID)-conjugated SN-38 Prodrug in A549 lung cancer cells. We found that Indomethacine–SN–38 (IndoSN-38) and Naproxen–SN–38(NaproSN-38) as a theranostic prodrug targeting cyclooxygenase-2(COX-2) in cancer cells inhibited A549 cell viability in a dose-dependent fashion. IndoSN-38 and NaproSN-38 inhibited A549 cell viability in a dose-dependent fashion. The suppression of A549 cell viability was due to induction of the cell apoptosis by enhancing the activities of Caspase 3 and Caspase 8. The cell cycle arrest of sub-G1 was found in the cells treated with IndoSN-38 or NaproSN-38. Collectively, these data suggested that the anti-proliferative activities of the NSAID-conjugated SN-38 prodrugs were due to promotion of cell death and arresting the cell cycle which was similar with those of SN-38. |
format | Online Article Text |
id | pubmed-10374863 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-103748632023-07-29 Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cells Kwon, Hae–Won An, Jusung Kim, Jong Seung Kang, In-Cheol Biochem Biophys Rep Research Article The goal of this paper was to look into the anti-tumor mechanism of Non-Steroidal Anti-Inflammatory Drug (NSAID)-conjugated SN-38 Prodrug in A549 lung cancer cells. We found that Indomethacine–SN–38 (IndoSN-38) and Naproxen–SN–38(NaproSN-38) as a theranostic prodrug targeting cyclooxygenase-2(COX-2) in cancer cells inhibited A549 cell viability in a dose-dependent fashion. IndoSN-38 and NaproSN-38 inhibited A549 cell viability in a dose-dependent fashion. The suppression of A549 cell viability was due to induction of the cell apoptosis by enhancing the activities of Caspase 3 and Caspase 8. The cell cycle arrest of sub-G1 was found in the cells treated with IndoSN-38 or NaproSN-38. Collectively, these data suggested that the anti-proliferative activities of the NSAID-conjugated SN-38 prodrugs were due to promotion of cell death and arresting the cell cycle which was similar with those of SN-38. Elsevier 2023-07-23 /pmc/articles/PMC10374863/ /pubmed/37521373 http://dx.doi.org/10.1016/j.bbrep.2023.101517 Text en © 2023 Published by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Kwon, Hae–Won An, Jusung Kim, Jong Seung Kang, In-Cheol Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cells |
title | Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cells |
title_full | Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cells |
title_fullStr | Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cells |
title_full_unstemmed | Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cells |
title_short | Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cells |
title_sort | inhibitory effects of nsaid-conjugated sn-38 on the viability of a549 non-small cell lung cancer cells |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374863/ https://www.ncbi.nlm.nih.gov/pubmed/37521373 http://dx.doi.org/10.1016/j.bbrep.2023.101517 |
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