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Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cells

The goal of this paper was to look into the anti-tumor mechanism of Non-Steroidal Anti-Inflammatory Drug (NSAID)-conjugated SN-38 Prodrug in A549 lung cancer cells. We found that Indomethacine–SN–38 (IndoSN-38) and Naproxen–SN–38(NaproSN-38) as a theranostic prodrug targeting cyclooxygenase-2(COX-2)...

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Autores principales: Kwon, Hae–Won, An, Jusung, Kim, Jong Seung, Kang, In-Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374863/
https://www.ncbi.nlm.nih.gov/pubmed/37521373
http://dx.doi.org/10.1016/j.bbrep.2023.101517
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author Kwon, Hae–Won
An, Jusung
Kim, Jong Seung
Kang, In-Cheol
author_facet Kwon, Hae–Won
An, Jusung
Kim, Jong Seung
Kang, In-Cheol
author_sort Kwon, Hae–Won
collection PubMed
description The goal of this paper was to look into the anti-tumor mechanism of Non-Steroidal Anti-Inflammatory Drug (NSAID)-conjugated SN-38 Prodrug in A549 lung cancer cells. We found that Indomethacine–SN–38 (IndoSN-38) and Naproxen–SN–38(NaproSN-38) as a theranostic prodrug targeting cyclooxygenase-2(COX-2) in cancer cells inhibited A549 cell viability in a dose-dependent fashion. IndoSN-38 and NaproSN-38 inhibited A549 cell viability in a dose-dependent fashion. The suppression of A549 cell viability was due to induction of the cell apoptosis by enhancing the activities of Caspase 3 and Caspase 8. The cell cycle arrest of sub-G1 was found in the cells treated with IndoSN-38 or NaproSN-38. Collectively, these data suggested that the anti-proliferative activities of the NSAID-conjugated SN-38 prodrugs were due to promotion of cell death and arresting the cell cycle which was similar with those of SN-38.
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spelling pubmed-103748632023-07-29 Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cells Kwon, Hae–Won An, Jusung Kim, Jong Seung Kang, In-Cheol Biochem Biophys Rep Research Article The goal of this paper was to look into the anti-tumor mechanism of Non-Steroidal Anti-Inflammatory Drug (NSAID)-conjugated SN-38 Prodrug in A549 lung cancer cells. We found that Indomethacine–SN–38 (IndoSN-38) and Naproxen–SN–38(NaproSN-38) as a theranostic prodrug targeting cyclooxygenase-2(COX-2) in cancer cells inhibited A549 cell viability in a dose-dependent fashion. IndoSN-38 and NaproSN-38 inhibited A549 cell viability in a dose-dependent fashion. The suppression of A549 cell viability was due to induction of the cell apoptosis by enhancing the activities of Caspase 3 and Caspase 8. The cell cycle arrest of sub-G1 was found in the cells treated with IndoSN-38 or NaproSN-38. Collectively, these data suggested that the anti-proliferative activities of the NSAID-conjugated SN-38 prodrugs were due to promotion of cell death and arresting the cell cycle which was similar with those of SN-38. Elsevier 2023-07-23 /pmc/articles/PMC10374863/ /pubmed/37521373 http://dx.doi.org/10.1016/j.bbrep.2023.101517 Text en © 2023 Published by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Kwon, Hae–Won
An, Jusung
Kim, Jong Seung
Kang, In-Cheol
Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cells
title Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cells
title_full Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cells
title_fullStr Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cells
title_full_unstemmed Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cells
title_short Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cells
title_sort inhibitory effects of nsaid-conjugated sn-38 on the viability of a549 non-small cell lung cancer cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374863/
https://www.ncbi.nlm.nih.gov/pubmed/37521373
http://dx.doi.org/10.1016/j.bbrep.2023.101517
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