Elevated PAF1-RAD52 axis confers chemoresistance to human cancers

Cisplatin- and gemcitabine-based chemotherapeutics represent a mainstay of cancer therapy for most solid tumors; however, resistance limits their curative potential. Here, we identify RNA polymerase II-associated factor 1 (PAF1) as a common driver of cisplatin and gemcitabine resistance in human can...

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Detalles Bibliográficos
Autores principales: Rauth, Sanchita, Ganguly, Koelina, Atri, Pranita, Parte, Seema, Nimmakayala, Rama Krishna, Varadharaj, Venkatesh, Nallasamy, Palanisamy, Vengoji, Raghupathy, Ogunleye, Ayoola O., Lakshmanan, Imayavaramban, Chirravuri, Ramakanth, Bessho, Mika, Cox, Jesse L., Foster, Jason M., Talmon, Geoffrey A., Bessho, Tadayoshi, Kishor Ganti, Apar, Batra, Surinder K., Ponnusamy, Moorthy P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374878/
https://www.ncbi.nlm.nih.gov/pubmed/36709426
http://dx.doi.org/10.1016/j.celrep.2023.112043

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