Rational engineering of an improved adenosine deaminase 2 enzyme for weaponizing T-cell therapies

Adenosine is a potent immunosuppressive metabolite that accumulates in the extracellular space within solid tumors and inhibits the antitumor function of native immune cell responses as well as chimeric antigen receptor (CAR) T-cell therapies. Here, we show that engineered human cells can degrade ex...

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Detalles Bibliográficos
Autores principales: Cox, J.R., Jennings, M., Lenahan, C., Manion, M., Courville, S., Blazeck, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374970/
https://www.ncbi.nlm.nih.gov/pubmed/37519414
http://dx.doi.org/10.1016/j.iotech.2023.100394

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