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Vpx requires active cellular dNTP biosynthesis to effectively counteract the anti-lentivirus activity of SAMHD1 in macrophages

HIV-1 replication in primary monocyte-derived macrophages (MDMs) is kinetically restricted at the reverse transcription step due to the low deoxynucleoside triphosphates (dNTP) pools established by host dNTPase, SAM and HD domain containing protein 1 (SAMHD1). Lentiviruses such as HIV-2 and some Sim...

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Detalles Bibliográficos
Autores principales:	Bowen, Nicole E., Tao, Sijia, Cho, Young-Jae, Schinazi, Raymond F., Kim, Baek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374972/ https://www.ncbi.nlm.nih.gov/pubmed/37390988 http://dx.doi.org/10.1016/j.jbc.2023.104984

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