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Comparing the efficacy of plasma exeresis and cryotherapy for the treatment of seborrheic keratosis: A randomized controlled trial
BACKGROUND: Seborrheic keratoses (SK) is a benign epithelial skin tumor and plasma exeresis is a new technique. AIMS: To compare the efficacy and safety of plasma exeresis and cryotherapy for treating SK. METHODS: This study is a randomized controlled trial (RCT). One side of each patient was random...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374986/ https://www.ncbi.nlm.nih.gov/pubmed/37632194 http://dx.doi.org/10.1111/srt.13429 |
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author | Noorbakhsh, Maryam Kalantari, Yasamin Ghasemi, Erfan Shokri, Babak Mahmoudi, Hamidreza Daneshpazhooh, Maryam Etesami, Ifa Khani, Mohammadreza |
author_facet | Noorbakhsh, Maryam Kalantari, Yasamin Ghasemi, Erfan Shokri, Babak Mahmoudi, Hamidreza Daneshpazhooh, Maryam Etesami, Ifa Khani, Mohammadreza |
author_sort | Noorbakhsh, Maryam |
collection | PubMed |
description | BACKGROUND: Seborrheic keratoses (SK) is a benign epithelial skin tumor and plasma exeresis is a new technique. AIMS: To compare the efficacy and safety of plasma exeresis and cryotherapy for treating SK. METHODS: This study is a randomized controlled trial (RCT). One side of each patient was randomly treated with plasma exeresis (peak‐to‐peak voltage of 3.44 kV and a frequency of 62.5 kHz) and the other side with cryotherapy. RESULTS: Thirty‐five males were enrolled. At week 3, 37.1 % (N = 13) of lesions treated by plasma exeresis were clear, which was higher than those treated by cryotherapy 17.1% (N = 6). However, this difference was not significant (p‐value: 0.06). At week 6, 16 (57.1 %) out of 28 remaining lesions, treated by plasma exeresis were clear, which was significantly higher (p‐value: 0.005) than those completely cleared by cryotherapy in 6 out of 29 remaining lesions (20.7%). The mean physician assessment scale score was significantly reduced in both groups in the second follow‐up (plasma group first follow‐up 0.91 ± 0.89 vs. second follow‐up 0.5 ± 0.64 and p‐value: 0.0031; cryo group first follow‐up 1.4 ± 0.84 vs. second follow‐up 1.1 ± 0.72 and p‐value: 0.0002). Regarding side effects, no significant difference was seen (p = 0.438). The most common complications in the plasma and cryotherapy groups were erythema (10/19, 52.63%) and hypo pigmentation (5/13, 38.46%). CONCLUSIONS: Both cryotherapy and plasma exeresis are effective. We observed a significantly higher cleared lesions treated with plasma exeresis in 6 weeks and after two sessions. |
format | Online Article Text |
id | pubmed-10374986 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103749862023-08-11 Comparing the efficacy of plasma exeresis and cryotherapy for the treatment of seborrheic keratosis: A randomized controlled trial Noorbakhsh, Maryam Kalantari, Yasamin Ghasemi, Erfan Shokri, Babak Mahmoudi, Hamidreza Daneshpazhooh, Maryam Etesami, Ifa Khani, Mohammadreza Skin Res Technol Original Articles BACKGROUND: Seborrheic keratoses (SK) is a benign epithelial skin tumor and plasma exeresis is a new technique. AIMS: To compare the efficacy and safety of plasma exeresis and cryotherapy for treating SK. METHODS: This study is a randomized controlled trial (RCT). One side of each patient was randomly treated with plasma exeresis (peak‐to‐peak voltage of 3.44 kV and a frequency of 62.5 kHz) and the other side with cryotherapy. RESULTS: Thirty‐five males were enrolled. At week 3, 37.1 % (N = 13) of lesions treated by plasma exeresis were clear, which was higher than those treated by cryotherapy 17.1% (N = 6). However, this difference was not significant (p‐value: 0.06). At week 6, 16 (57.1 %) out of 28 remaining lesions, treated by plasma exeresis were clear, which was significantly higher (p‐value: 0.005) than those completely cleared by cryotherapy in 6 out of 29 remaining lesions (20.7%). The mean physician assessment scale score was significantly reduced in both groups in the second follow‐up (plasma group first follow‐up 0.91 ± 0.89 vs. second follow‐up 0.5 ± 0.64 and p‐value: 0.0031; cryo group first follow‐up 1.4 ± 0.84 vs. second follow‐up 1.1 ± 0.72 and p‐value: 0.0002). Regarding side effects, no significant difference was seen (p = 0.438). The most common complications in the plasma and cryotherapy groups were erythema (10/19, 52.63%) and hypo pigmentation (5/13, 38.46%). CONCLUSIONS: Both cryotherapy and plasma exeresis are effective. We observed a significantly higher cleared lesions treated with plasma exeresis in 6 weeks and after two sessions. John Wiley and Sons Inc. 2023-07-27 /pmc/articles/PMC10374986/ /pubmed/37632194 http://dx.doi.org/10.1111/srt.13429 Text en © 2023 The Authors. Skin Research and Technology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Noorbakhsh, Maryam Kalantari, Yasamin Ghasemi, Erfan Shokri, Babak Mahmoudi, Hamidreza Daneshpazhooh, Maryam Etesami, Ifa Khani, Mohammadreza Comparing the efficacy of plasma exeresis and cryotherapy for the treatment of seborrheic keratosis: A randomized controlled trial |
title | Comparing the efficacy of plasma exeresis and cryotherapy for the treatment of seborrheic keratosis: A randomized controlled trial |
title_full | Comparing the efficacy of plasma exeresis and cryotherapy for the treatment of seborrheic keratosis: A randomized controlled trial |
title_fullStr | Comparing the efficacy of plasma exeresis and cryotherapy for the treatment of seborrheic keratosis: A randomized controlled trial |
title_full_unstemmed | Comparing the efficacy of plasma exeresis and cryotherapy for the treatment of seborrheic keratosis: A randomized controlled trial |
title_short | Comparing the efficacy of plasma exeresis and cryotherapy for the treatment of seborrheic keratosis: A randomized controlled trial |
title_sort | comparing the efficacy of plasma exeresis and cryotherapy for the treatment of seborrheic keratosis: a randomized controlled trial |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374986/ https://www.ncbi.nlm.nih.gov/pubmed/37632194 http://dx.doi.org/10.1111/srt.13429 |
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