Single‐Cell RNA Sequencing and Spatial Transcriptomics Reveal Pathogenesis of Meningeal Lymphatic Dysfunction after Experimental Subarachnoid Hemorrhage (Adv. Sci. 21/2023)

Subarachnoid Hemorrhage Meningeal lymphatic vessels (mLVs) are newly discovered intracranial fluid transport system and have been proved to drain extravasated erythrocytes from cerebrospinal fluid into deep cervical lymph nodes (dCLNs) after subarachnoid hemorrhage (SAH). In article number 2301428, Kaikai Wang, Sheng Chen, Jianmin Zhang, and co‐workers applied single‐cell RNA sequencing and spatial transcriptomics to investigate the alteration of cellular, molecular and spatial pattern of mLVs after SAH for the first time. This study reveals thrombospondin 1‐CD47 ligand–receptor pair plays a key role in meningeal lymphatic endothelial cells apoptosis via regulating STAT3/Bcl‐2 signaling, which filled a knowledge gap in our understanding of the pathogenesis of mLVs injury after SAH. [Image: see text]