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Coupling the H295R with ERα and AR U2OS CALUX assays enables simultaneous testing for estrogenic, anti-androgenic and steroidogenic modalities

Endocrine active substances, including steroidogenesis modulators, have received increased attention. The in vitro H295R steroidogenesis assay (OECD TG 456) is commonly used to test for this modality. However, current detection methods often fail to capture alterations to estrogen biosynthesis. The...

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Detalles Bibliográficos
Autores principales:	Nikopaschou, Martha S, Félix, Alexandre, Mollergues, Julie, Scholz, Gabriele, Schilter, Benoit, Marin-Kuan, Maricel, Fussell, Karma C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Endocrine Toxicology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10375316/ https://www.ncbi.nlm.nih.gov/pubmed/37261848 http://dx.doi.org/10.1093/toxsci/kfad052

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