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Spacer Fidelity Assessments of Guide RNA by Top-Down Mass Spectrometry

[Image: see text] The advancement of CRISPR-based gene editing tools into biotherapeutics offers the potential for cures to genetic disorders and for new treatment paradigms for even common diseases. Arguably, the most important component of a CRISPR-based medicine is the guide RNA, which is general...

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Detalles Bibliográficos
Autores principales:	Macias, Luis A., Garcia, Sara P., Back, Kayla M., Wu, Yue, Johnson, G. Hall, Kathiresan, Sekar, Bellinger, Andrew M., Rohde, Ellen, Freitas, Michael A., Madsen, James A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10375574/ https://www.ncbi.nlm.nih.gov/pubmed/37521788 http://dx.doi.org/10.1021/acscentsci.3c00289

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