Why estimands are needed to define treatment effects in clinical trials

BACKGROUND: The estimand for a clinical trial is a precise definition of the treatment effect to be estimated. Traditionally, estimates of treatment effects are based on either an ITT analysis or a per-protocol analysis. However, there are important clinical questions which are not addressed by eith...

Descripción completa

Detalles Bibliográficos
Autores principales: Keene, Oliver N., Lynggaard, Helle, Englert, Stefan, Lanius, Vivian, Wright, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10375689/
https://www.ncbi.nlm.nih.gov/pubmed/37501156
http://dx.doi.org/10.1186/s12916-023-02969-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10375689/
https://www.ncbi.nlm.nih.gov/pubmed/37501156
http://dx.doi.org/10.1186/s12916-023-02969-6

Ejemplares similares