Cargando…

Cytokine response and damages in the lungs of aging Syrian hamsters on a high-fat diet infected with the SARS-CoV-2 virus

Hypertriglyceridemia, obesity, and aging are among the key risk factors for severe COVID-19 with acute respiratory distress syndrome (ARDS). One of the main prognostic biomarkers of ARDS is the level of cytokines IL-6 and TNF-α in the blood. In our study, we modeled hyperglyceridemia and hypercholes...

Descripción completa

Detalles Bibliográficos
Autores principales: Fomin, Gleb, Tabynov, Kairat, Islamov, Rinat, Turebekov, Nurkeldi, Yessimseit, Duman, Yerubaev, Toktasyn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10375707/
https://www.ncbi.nlm.nih.gov/pubmed/37520568
http://dx.doi.org/10.3389/fimmu.2023.1223086
_version_ 1785079093585248256
author Fomin, Gleb
Tabynov, Kairat
Islamov, Rinat
Turebekov, Nurkeldi
Yessimseit, Duman
Yerubaev, Toktasyn
author_facet Fomin, Gleb
Tabynov, Kairat
Islamov, Rinat
Turebekov, Nurkeldi
Yessimseit, Duman
Yerubaev, Toktasyn
author_sort Fomin, Gleb
collection PubMed
description Hypertriglyceridemia, obesity, and aging are among the key risk factors for severe COVID-19 with acute respiratory distress syndrome (ARDS). One of the main prognostic biomarkers of ARDS is the level of cytokines IL-6 and TNF-α in the blood. In our study, we modeled hyperglyceridemia and hypercholesterolemia on 18-month-old Syrian hamsters (Mesocricetus auratus). By 18 months, the animals showed such markers of aging as weight stabilization with a tendency to reduce it, polycystic liver disease, decreased motor activity, and foci of alopecia. The high-fat diet caused an increase in triglycerides and cholesterol, as well as fatty changes in the liver. On the third day after infection with the SARS-CoV-2 virus, animals showed a decrease in weight in the groups with a high-fat diet. In the lungs of males on both diets, there was an increase in the concentration of IFN-α, as well as IL-6 in both males and females, regardless of the type of diet. At the same time, the levels of TNF-α and IFN-γ did not change in infected animals. Morphological studies of the lungs of hamsters with SARS-CoV-2 showed the presence of a pathological process characteristic of ARDS. These included bronchointerstitial pneumonia and diffuse alveolar damages. These observations suggest that in aging hamsters, the immune response to pro-inflammatory cytokines may be delayed to a later period. Hypertriglyceridemia, age, and gender affect the severity of COVID-19. These results will help to understand the pathogenesis of COVID-19 associated with age, gender, and disorders of fat metabolism in humans.
format Online
Article
Text
id pubmed-10375707
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-103757072023-07-29 Cytokine response and damages in the lungs of aging Syrian hamsters on a high-fat diet infected with the SARS-CoV-2 virus Fomin, Gleb Tabynov, Kairat Islamov, Rinat Turebekov, Nurkeldi Yessimseit, Duman Yerubaev, Toktasyn Front Immunol Immunology Hypertriglyceridemia, obesity, and aging are among the key risk factors for severe COVID-19 with acute respiratory distress syndrome (ARDS). One of the main prognostic biomarkers of ARDS is the level of cytokines IL-6 and TNF-α in the blood. In our study, we modeled hyperglyceridemia and hypercholesterolemia on 18-month-old Syrian hamsters (Mesocricetus auratus). By 18 months, the animals showed such markers of aging as weight stabilization with a tendency to reduce it, polycystic liver disease, decreased motor activity, and foci of alopecia. The high-fat diet caused an increase in triglycerides and cholesterol, as well as fatty changes in the liver. On the third day after infection with the SARS-CoV-2 virus, animals showed a decrease in weight in the groups with a high-fat diet. In the lungs of males on both diets, there was an increase in the concentration of IFN-α, as well as IL-6 in both males and females, regardless of the type of diet. At the same time, the levels of TNF-α and IFN-γ did not change in infected animals. Morphological studies of the lungs of hamsters with SARS-CoV-2 showed the presence of a pathological process characteristic of ARDS. These included bronchointerstitial pneumonia and diffuse alveolar damages. These observations suggest that in aging hamsters, the immune response to pro-inflammatory cytokines may be delayed to a later period. Hypertriglyceridemia, age, and gender affect the severity of COVID-19. These results will help to understand the pathogenesis of COVID-19 associated with age, gender, and disorders of fat metabolism in humans. Frontiers Media S.A. 2023-07-14 /pmc/articles/PMC10375707/ /pubmed/37520568 http://dx.doi.org/10.3389/fimmu.2023.1223086 Text en Copyright © 2023 Fomin, Tabynov, Islamov, Turebekov, Yessimseit and Yerubaev https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Fomin, Gleb
Tabynov, Kairat
Islamov, Rinat
Turebekov, Nurkeldi
Yessimseit, Duman
Yerubaev, Toktasyn
Cytokine response and damages in the lungs of aging Syrian hamsters on a high-fat diet infected with the SARS-CoV-2 virus
title Cytokine response and damages in the lungs of aging Syrian hamsters on a high-fat diet infected with the SARS-CoV-2 virus
title_full Cytokine response and damages in the lungs of aging Syrian hamsters on a high-fat diet infected with the SARS-CoV-2 virus
title_fullStr Cytokine response and damages in the lungs of aging Syrian hamsters on a high-fat diet infected with the SARS-CoV-2 virus
title_full_unstemmed Cytokine response and damages in the lungs of aging Syrian hamsters on a high-fat diet infected with the SARS-CoV-2 virus
title_short Cytokine response and damages in the lungs of aging Syrian hamsters on a high-fat diet infected with the SARS-CoV-2 virus
title_sort cytokine response and damages in the lungs of aging syrian hamsters on a high-fat diet infected with the sars-cov-2 virus
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10375707/
https://www.ncbi.nlm.nih.gov/pubmed/37520568
http://dx.doi.org/10.3389/fimmu.2023.1223086
work_keys_str_mv AT fomingleb cytokineresponseanddamagesinthelungsofagingsyrianhamstersonahighfatdietinfectedwiththesarscov2virus
AT tabynovkairat cytokineresponseanddamagesinthelungsofagingsyrianhamstersonahighfatdietinfectedwiththesarscov2virus
AT islamovrinat cytokineresponseanddamagesinthelungsofagingsyrianhamstersonahighfatdietinfectedwiththesarscov2virus
AT turebekovnurkeldi cytokineresponseanddamagesinthelungsofagingsyrianhamstersonahighfatdietinfectedwiththesarscov2virus
AT yessimseitduman cytokineresponseanddamagesinthelungsofagingsyrianhamstersonahighfatdietinfectedwiththesarscov2virus
AT yerubaevtoktasyn cytokineresponseanddamagesinthelungsofagingsyrianhamstersonahighfatdietinfectedwiththesarscov2virus