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Obstructive sleep apnea event detection using explainable deep learning models for a portable monitor

BACKGROUND: Polysomnography (PSG) is the gold standard for detecting obstructive sleep apnea (OSA). However, this technique has many disadvantages when using it outside the hospital or for daily use. Portable monitors (PMs) aim to streamline the OSA detection process through deep learning (DL). MATE...

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Autores principales: Alarcón, Ángel Serrano, Madrid, Natividad Martínez, Seepold, Ralf, Ortega, Juan Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10375719/
https://www.ncbi.nlm.nih.gov/pubmed/37521695
http://dx.doi.org/10.3389/fnins.2023.1155900
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author Alarcón, Ángel Serrano
Madrid, Natividad Martínez
Seepold, Ralf
Ortega, Juan Antonio
author_facet Alarcón, Ángel Serrano
Madrid, Natividad Martínez
Seepold, Ralf
Ortega, Juan Antonio
author_sort Alarcón, Ángel Serrano
collection PubMed
description BACKGROUND: Polysomnography (PSG) is the gold standard for detecting obstructive sleep apnea (OSA). However, this technique has many disadvantages when using it outside the hospital or for daily use. Portable monitors (PMs) aim to streamline the OSA detection process through deep learning (DL). MATERIALS AND METHODS: We studied how to detect OSA events and calculate the apnea-hypopnea index (AHI) by using deep learning models that aim to be implemented on PMs. Several deep learning models are presented after being trained on polysomnography data from the National Sleep Research Resource (NSRR) repository. The best hyperparameters for the DL architecture are presented. In addition, emphasis is focused on model explainability techniques, concretely on Gradient-weighted Class Activation Mapping (Grad-CAM). RESULTS: The results for the best DL model are presented and analyzed. The interpretability of the DL model is also analyzed by studying the regions of the signals that are most relevant for the model to make the decision. The model that yields the best result is a one-dimensional convolutional neural network (1D-CNN) with 84.3% accuracy. CONCLUSION: The use of PMs using machine learning techniques for detecting OSA events still has a long way to go. However, our method for developing explainable DL models demonstrates that PMs appear to be a promising alternative to PSG in the future for the detection of obstructive apnea events and the automatic calculation of AHI.
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spelling pubmed-103757192023-07-29 Obstructive sleep apnea event detection using explainable deep learning models for a portable monitor Alarcón, Ángel Serrano Madrid, Natividad Martínez Seepold, Ralf Ortega, Juan Antonio Front Neurosci Neuroscience BACKGROUND: Polysomnography (PSG) is the gold standard for detecting obstructive sleep apnea (OSA). However, this technique has many disadvantages when using it outside the hospital or for daily use. Portable monitors (PMs) aim to streamline the OSA detection process through deep learning (DL). MATERIALS AND METHODS: We studied how to detect OSA events and calculate the apnea-hypopnea index (AHI) by using deep learning models that aim to be implemented on PMs. Several deep learning models are presented after being trained on polysomnography data from the National Sleep Research Resource (NSRR) repository. The best hyperparameters for the DL architecture are presented. In addition, emphasis is focused on model explainability techniques, concretely on Gradient-weighted Class Activation Mapping (Grad-CAM). RESULTS: The results for the best DL model are presented and analyzed. The interpretability of the DL model is also analyzed by studying the regions of the signals that are most relevant for the model to make the decision. The model that yields the best result is a one-dimensional convolutional neural network (1D-CNN) with 84.3% accuracy. CONCLUSION: The use of PMs using machine learning techniques for detecting OSA events still has a long way to go. However, our method for developing explainable DL models demonstrates that PMs appear to be a promising alternative to PSG in the future for the detection of obstructive apnea events and the automatic calculation of AHI. Frontiers Media S.A. 2023-07-14 /pmc/articles/PMC10375719/ /pubmed/37521695 http://dx.doi.org/10.3389/fnins.2023.1155900 Text en Copyright © 2023 Alarcón, Madrid, Seepold and Ortega. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Alarcón, Ángel Serrano
Madrid, Natividad Martínez
Seepold, Ralf
Ortega, Juan Antonio
Obstructive sleep apnea event detection using explainable deep learning models for a portable monitor
title Obstructive sleep apnea event detection using explainable deep learning models for a portable monitor
title_full Obstructive sleep apnea event detection using explainable deep learning models for a portable monitor
title_fullStr Obstructive sleep apnea event detection using explainable deep learning models for a portable monitor
title_full_unstemmed Obstructive sleep apnea event detection using explainable deep learning models for a portable monitor
title_short Obstructive sleep apnea event detection using explainable deep learning models for a portable monitor
title_sort obstructive sleep apnea event detection using explainable deep learning models for a portable monitor
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10375719/
https://www.ncbi.nlm.nih.gov/pubmed/37521695
http://dx.doi.org/10.3389/fnins.2023.1155900
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