Multidimensional biomarkers for multiple system atrophy: an update and future directions

Multiple system atrophy (MSA) is a fatal progressive neurodegenerative disease. Biomarkers are urgently required for MSA to improve the diagnostic and prognostic accuracy in clinic and facilitate the development and monitoring of disease-modifying therapies. In recent years, significant research eff...

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Autores principales: Wan, Linlin, Zhu, Sudan, Chen, Zhao, Qiu, Rong, Tang, Beisha, Jiang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10375766/
https://www.ncbi.nlm.nih.gov/pubmed/37501056
http://dx.doi.org/10.1186/s40035-023-00370-0
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author Wan, Linlin
Zhu, Sudan
Chen, Zhao
Qiu, Rong
Tang, Beisha
Jiang, Hong
author_facet Wan, Linlin
Zhu, Sudan
Chen, Zhao
Qiu, Rong
Tang, Beisha
Jiang, Hong
author_sort Wan, Linlin
collection PubMed
description Multiple system atrophy (MSA) is a fatal progressive neurodegenerative disease. Biomarkers are urgently required for MSA to improve the diagnostic and prognostic accuracy in clinic and facilitate the development and monitoring of disease-modifying therapies. In recent years, significant research efforts have been made in exploring multidimensional biomarkers for MSA. However, currently few biomarkers are available in clinic. In this review, we systematically summarize the latest advances in multidimensional biomarkers for MSA, including biomarkers in fluids, tissues and gut microbiota as well as imaging biomarkers. Future directions for exploration of novel biomarkers and promotion of implementation in clinic are also discussed.
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spelling pubmed-103757662023-07-29 Multidimensional biomarkers for multiple system atrophy: an update and future directions Wan, Linlin Zhu, Sudan Chen, Zhao Qiu, Rong Tang, Beisha Jiang, Hong Transl Neurodegener Review Multiple system atrophy (MSA) is a fatal progressive neurodegenerative disease. Biomarkers are urgently required for MSA to improve the diagnostic and prognostic accuracy in clinic and facilitate the development and monitoring of disease-modifying therapies. In recent years, significant research efforts have been made in exploring multidimensional biomarkers for MSA. However, currently few biomarkers are available in clinic. In this review, we systematically summarize the latest advances in multidimensional biomarkers for MSA, including biomarkers in fluids, tissues and gut microbiota as well as imaging biomarkers. Future directions for exploration of novel biomarkers and promotion of implementation in clinic are also discussed. BioMed Central 2023-07-28 /pmc/articles/PMC10375766/ /pubmed/37501056 http://dx.doi.org/10.1186/s40035-023-00370-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Wan, Linlin
Zhu, Sudan
Chen, Zhao
Qiu, Rong
Tang, Beisha
Jiang, Hong
Multidimensional biomarkers for multiple system atrophy: an update and future directions
title Multidimensional biomarkers for multiple system atrophy: an update and future directions
title_full Multidimensional biomarkers for multiple system atrophy: an update and future directions
title_fullStr Multidimensional biomarkers for multiple system atrophy: an update and future directions
title_full_unstemmed Multidimensional biomarkers for multiple system atrophy: an update and future directions
title_short Multidimensional biomarkers for multiple system atrophy: an update and future directions
title_sort multidimensional biomarkers for multiple system atrophy: an update and future directions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10375766/
https://www.ncbi.nlm.nih.gov/pubmed/37501056
http://dx.doi.org/10.1186/s40035-023-00370-0
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