New Pathway for Cisplatin Prodrug to Utilize Metabolic Substrate Preference to Overcome Cancer Intrinsic Resistance

[Image: see text] Tumor cells adapt to diverse survival strategies defying our pursuit of multimodal cancer therapy. Prostate cancer (PCa) is an example that is resistant to one of the most potent chemotherapeutics, cisplatin. PCa cells survive and proliferate using fatty acid oxidation (FAO), and t...

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Detalles Bibliográficos
Autores principales: Kalathil, Akil A., Guin, Subham, Ashokan, Akash, Basu, Uttara, Surnar, Bapurao, Delma, Katiana S., Lima, Leonor M., Kryvenko, Oleksandr N., Dhar, Shanta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10375877/
https://www.ncbi.nlm.nih.gov/pubmed/37521786
http://dx.doi.org/10.1021/acscentsci.3c00286

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