Cargando…

Repurposed Fenoprofen Targeting SaeR Attenuates Staphylococcus aureus Virulence in Implant-Associated Infections

[Image: see text] Implant-associated infections (IAIs) caused by S. aureus can result in serious challenges after orthopedic surgery. Due to biofilm formation and antibiotic resistance, this refractory infection is highly prevalent, and finding drugs to attenuate bacterial virulence is becoming a ra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Feng, Chen, Yingjia, Yu, Jinlong, Zhang, Feiyang, Liu, Qian, He, Lei, Musha, Hamushan, Du, Jiafei, Wang, Boyong, Han, Pei, Chen, Xiaohua, Tang, Jin, Li, Min, Shen, Hao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10375895/ https://www.ncbi.nlm.nih.gov/pubmed/37521790 http://dx.doi.org/10.1021/acscentsci.3c00499

Ejemplares similares

Aspartic Acid Residue 51 of SaeR Is Essential for Staphylococcus aureus Virulence
por: Nygaard, Tyler K., et al.
Publicado: (2018)

The SaeRS Two-Component System of Staphylococcus aureus
por: Liu, Qian, et al.
Publicado: (2016)

NWMN2330 May Be Associated with the Virulence of Staphylococcus aureus by Increasing the Expression of hla and saeRS
por: Liu, Li, et al.
Publicado: (2022)

SaeRS-Dependent Inhibition of Biofilm Formation in Staphylococcus aureus Newman
por: Cue, David, et al.
Publicado: (2015)

A General Map of Transcriptional Expression of Virulence, Metabolism, and Biofilm Formation Adaptive Changes of Staphylococcus aureus When Exposed to Different Antimicrobials
por: Ren, Zun, et al.
Publicado: (2022)

SaeR as a novel target for antivirulence therapy against Staphylococcus aureus
por: Gao, Peng, et al.
Publicado: (2023)

The Accessory Gene saeP of the SaeR/S Two-Component Gene Regulatory System Impacts Staphylococcus aureus Virulence During Neutrophil Interaction
por: Collins, Madison M., et al.
Publicado: (2020)

The Small Protein ScrA Influences Staphylococcus aureus Virulence-Related Processes via the SaeRS System
por: Wittekind, Marcus A., et al.
Publicado: (2023)

Commensal Staphylococcus epidermidis Defends against Staphylococcus aureus through SaeRS Two-Component System
por: Nurxat, Nadira, et al.
Publicado: (2023)

Role of Fatty Acid Kinase in Cellular Lipid Homeostasis and SaeRS-Dependent Virulence Factor Expression in Staphylococcus aureus
por: Ericson, Megan E., et al.
Publicado: (2017)

Single-cell transcriptome reveals Staphylococcus aureus modulating fibroblast differentiation in the bone-implant interface
por: Yu, Jinlong, et al.
Publicado: (2023)

Subinhibitory concentrations of resveratrol reduce alpha-hemolysin production in Staphylococcus aureus isolates by downregulating saeRS
por: Duan, Jingjing, et al.
Publicado: (2018)

The novel protein ScrA acts through the SaeRS two‐component system to regulate virulence gene expression in Staphylococcus aureus
por: Wittekind, Marcus A., et al.
Publicado: (2022)

Characterization and virulence of Streptococcus agalactiae deficient in SaeRS of the two-component system
por: Li, Shiyu, et al.
Publicado: (2023)

Identification of Staphylococcus aureus virulence-modulating RNA from transcriptomics data with machine learning
por: Yu, Jinlong, et al.
Publicado: (2023)

saeRS and sarA Act Synergistically to Repress Protease Production and Promote Biofilm Formation in Staphylococcus aureus
por: Mrak, Lara N., et al.
Publicado: (2012)

Calprotectin Increases the Activity of the SaeRS Two Component System and Murine Mortality during Staphylococcus aureus Infections
por: Cho, Hoonsik, et al.
Publicado: (2015)

The SaeRS Two-Component System Controls Survival of Staphylococcus aureus in Human Blood through Regulation of Coagulase
por: Guo, Haiyong, et al.
Publicado: (2017)

Molybdopterin biosynthesis pathway contributes to the regulation of SaeRS two-component system by ClpP in Staphylococcus aureus
por: Zhao, Na, et al.
Publicado: (2022)

Thermonucleases Contribute to Staphylococcus aureus Biofilm Formation in Implant-Associated Infections–A Redundant and Complementary Story
por: Yu, Jinlong, et al.
Publicado: (2021)

The SaeR/S Gene Regulatory System Induces a Pro-Inflammatory Cytokine Response during Staphylococcus aureus Infection
por: Watkins, Robert L., et al.
Publicado: (2011)

Inhibition of Rho Activity Increases Expression of SaeRS-Dependent Virulence Factor Genes in Staphylococcus aureus, Showing a Link between Transcription Termination, Antibiotic Action, and Virulence
por: Nagel, Anna, et al.
Publicado: (2018)

Exploiting Correlations between Protein Abundance and the Functional Status of saeRS and sarA To Identify Virulence Factors of Potential Importance in the Pathogenesis of Staphylococcus aureus Osteomyelitis
por: Ramirez, Aura M., et al.
Publicado: (2019)

Role of the SaeRS two-component regulatory system in Staphylococcus epidermidis autolysis and biofilm formation
por: Lou, Qiang, et al.
Publicado: (2011)

A Critical Role for HlgA in Staphylococcus aureus Pathogenesis Revealed by A Switch in the SaeRS Two-Component Regulatory System
por: Venkatasubramaniam, Arundhathi, et al.
Publicado: (2018)

Two-Component Signal Transduction System SaeRS Positively Regulates Staphylococcus epidermidis Glucose Metabolism
por: Lou, Qiang, et al.
Publicado: (2014)

Stochastic Expression of Sae-Dependent Virulence Genes during Staphylococcus aureus Biofilm Development Is Dependent on SaeS
por: DelMain, Elizabeth A., et al.
Publicado: (2020)

Subinhibitory Concentrations of Fusidic Acid May Reduce the Virulence of S. aureus by Down-Regulating sarA and saeRS to Reduce Biofilm Formation and α-Toxin Expression
por: Liu, Li, et al.
Publicado: (2020)

Contribution of Coagulase and Its Regulator SaeRS to Lethality of CA-MRSA 923 Bacteremia
por: Liu, Ying, et al.
Publicado: (2021)

SDS Interferes with SaeS Signaling of Staphylococcus aureus Independently of SaePQ
por: Makgotlho, Phuti E., et al.
Publicado: (2013)

Importance of the Global Regulators Agr and SaeRS in the Pathogenesis of CA-MRSA USA300 Infection
por: Montgomery, Christopher P., et al.
Publicado: (2010)

Key role of quorum‐sensing mutations in the development of Staphylococcus aureus clinical device‐associated infection
por: He, Lei, et al.
Publicado: (2022)

Downstream element determines RNase Y cleavage of the saePQRS operon in Staphylococcus aureus
por: Marincola, Gabriella, et al.
Publicado: (2017)

Regulation of the Sae Two-Component System by Branched-Chain Fatty Acids in Staphylococcus aureus
por: Pendleton, Augustus, et al.
Publicado: (2022)

Sub-Inhibitory Concentrations of Mupirocin Strongly Inhibit Alpha-Toxin Production in High-Level Mupirocin-Resistant MRSA by Down-Regulating agr, saeRS, and sarA
por: Jin, Ye, et al.
Publicado: (2018)

Trends in microbiological epidemiology of orthopedic infections: a large retrospective study from 2008 to 2021
por: Wang, Boyong, et al.
Publicado: (2023)

Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3
por: Montero-Melendez, Trinidad, et al.
Publicado: (2016)

Rewiring of the FtsH regulatory network by a single nucleotide change in saeS of Staphylococcus aureus
por: Liu, Qian, et al.
Publicado: (2017)

Counter inhibition between leukotoxins attenuates Staphylococcus aureus virulence
por: Yoong, Pauline, et al.
Publicado: (2015)

Targeting host deoxycytidine kinase attenuates Staphylococcus aureus virulence
por: Winstel, Volker, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_8j2ethplo1gguom1da18oh8dkv