New NADPH Oxidase 2 Inhibitors Display Potent Activity against Oxidative Stress by Targeting p22(phox)-p47(phox) Interactions

NADPH oxidase (NOX2) is responsible for reactive oxygen species (ROS) production in neutrophils and has been recognized as a key mediator in inflammatory and cardiovascular pathologies. Nevertheless, there is a lack of specific NOX2 pharmacological inhibitors. In medicinal chemistry, heterocyclic co...

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Detalles Bibliográficos
Autores principales: Treuer, Adriana V., Faúndez, Mario, Ebensperger, Roberto, Hovelmeyer, Erwin, Vergara-Jaque, Ariela, Perera-Sardiña, Yunier, Gutierrez, Margarita, Fuentealba, Roberto, González, Daniel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376059/
https://www.ncbi.nlm.nih.gov/pubmed/37507978
http://dx.doi.org/10.3390/antiox12071441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376059/
https://www.ncbi.nlm.nih.gov/pubmed/37507978
http://dx.doi.org/10.3390/antiox12071441

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