Mechanistic Understanding of Idiosyncratic Drug-Induced Hepatotoxicity Using Co-Cultures of Hepatocytes and Macrophages

Hepatotoxicity or drug-induced liver injury (DILI) is a major safety issue in drug development as a primary reason for drug failure in clinical trials and the main cause for post-marketing regulatory measures like drug withdrawal. Idiosyncratic DILI (iDILI) is a patient-specific, multifactorial, and...

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Detalles Bibliográficos
Autores principales: Villanueva-Badenas, Estela, Donato, M. Teresa, Tolosa, Laia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376129/
https://www.ncbi.nlm.nih.gov/pubmed/37507855
http://dx.doi.org/10.3390/antiox12071315

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