Cargando…

Cancer Drug Delivery Systems Using Bacterial Toxin Translocation Mechanisms

Recent advances in targeted cancer therapy hold great promise for both research and clinical applications and push the boundaries in finding new treatments for various currently incurable cancers. However, these therapies require specific cell-targeting mechanisms for the efficient delivery of drug...

Descripción completa

Detalles Bibliográficos
Autores principales: Yin, Linxiang, Thaker, Hatim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376142/
https://www.ncbi.nlm.nih.gov/pubmed/37508840
http://dx.doi.org/10.3390/bioengineering10070813
_version_ 1785079197508567040
author Yin, Linxiang
Thaker, Hatim
author_facet Yin, Linxiang
Thaker, Hatim
author_sort Yin, Linxiang
collection PubMed
description Recent advances in targeted cancer therapy hold great promise for both research and clinical applications and push the boundaries in finding new treatments for various currently incurable cancers. However, these therapies require specific cell-targeting mechanisms for the efficient delivery of drug cargo across the cell membrane to reach intracellular targets and avoid diffusion to unwanted tissues. Traditional drug delivery systems suffer from a limited ability to travel across the barriers posed by cell membranes and, therefore, there is a need for high doses, which are associated with adverse reactions and safety concerns. Bacterial toxins have evolved naturally to specifically target cell subtypes via their receptor binding module, penetrating the cell membrane efficiently through the membrane translocation process and then successfully delivering the toxic cargo into the host cytosol. They have, thus, been harnessed for the delivery of various drugs. In this review, we focus on bacterial toxin translocation mechanisms and recent progress in the targeted delivery systems of cancer therapy drugs that have been inspired by the receptor binding and membrane translocation processes of the anthrax toxin protective antigen, diphtheria toxin, and Pseudomonas exotoxin A. We also discuss the challenges and limitations of these studies that should be addressed before bacterial toxin-based drug delivery systems can become a viable new generation of drug delivery approaches in clinical translation.
format Online
Article
Text
id pubmed-10376142
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-103761422023-07-29 Cancer Drug Delivery Systems Using Bacterial Toxin Translocation Mechanisms Yin, Linxiang Thaker, Hatim Bioengineering (Basel) Review Recent advances in targeted cancer therapy hold great promise for both research and clinical applications and push the boundaries in finding new treatments for various currently incurable cancers. However, these therapies require specific cell-targeting mechanisms for the efficient delivery of drug cargo across the cell membrane to reach intracellular targets and avoid diffusion to unwanted tissues. Traditional drug delivery systems suffer from a limited ability to travel across the barriers posed by cell membranes and, therefore, there is a need for high doses, which are associated with adverse reactions and safety concerns. Bacterial toxins have evolved naturally to specifically target cell subtypes via their receptor binding module, penetrating the cell membrane efficiently through the membrane translocation process and then successfully delivering the toxic cargo into the host cytosol. They have, thus, been harnessed for the delivery of various drugs. In this review, we focus on bacterial toxin translocation mechanisms and recent progress in the targeted delivery systems of cancer therapy drugs that have been inspired by the receptor binding and membrane translocation processes of the anthrax toxin protective antigen, diphtheria toxin, and Pseudomonas exotoxin A. We also discuss the challenges and limitations of these studies that should be addressed before bacterial toxin-based drug delivery systems can become a viable new generation of drug delivery approaches in clinical translation. MDPI 2023-07-07 /pmc/articles/PMC10376142/ /pubmed/37508840 http://dx.doi.org/10.3390/bioengineering10070813 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yin, Linxiang
Thaker, Hatim
Cancer Drug Delivery Systems Using Bacterial Toxin Translocation Mechanisms
title Cancer Drug Delivery Systems Using Bacterial Toxin Translocation Mechanisms
title_full Cancer Drug Delivery Systems Using Bacterial Toxin Translocation Mechanisms
title_fullStr Cancer Drug Delivery Systems Using Bacterial Toxin Translocation Mechanisms
title_full_unstemmed Cancer Drug Delivery Systems Using Bacterial Toxin Translocation Mechanisms
title_short Cancer Drug Delivery Systems Using Bacterial Toxin Translocation Mechanisms
title_sort cancer drug delivery systems using bacterial toxin translocation mechanisms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376142/
https://www.ncbi.nlm.nih.gov/pubmed/37508840
http://dx.doi.org/10.3390/bioengineering10070813
work_keys_str_mv AT yinlinxiang cancerdrugdeliverysystemsusingbacterialtoxintranslocationmechanisms
AT thakerhatim cancerdrugdeliverysystemsusingbacterialtoxintranslocationmechanisms