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Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases?

Optic nerve disorders encompass a wide spectrum of conditions characterized by the loss of retinal ganglion cells (RGCs) and subsequent degeneration of the optic nerve. The etiology of these disorders can vary significantly, but emerging research highlights the crucial role of oxidative stress, an i...

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Autores principales: Buonfiglio, Francesco, Böhm, Elsa Wilma, Pfeiffer, Norbert, Gericke, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376185/
https://www.ncbi.nlm.nih.gov/pubmed/37508003
http://dx.doi.org/10.3390/antiox12071465
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author Buonfiglio, Francesco
Böhm, Elsa Wilma
Pfeiffer, Norbert
Gericke, Adrian
author_facet Buonfiglio, Francesco
Böhm, Elsa Wilma
Pfeiffer, Norbert
Gericke, Adrian
author_sort Buonfiglio, Francesco
collection PubMed
description Optic nerve disorders encompass a wide spectrum of conditions characterized by the loss of retinal ganglion cells (RGCs) and subsequent degeneration of the optic nerve. The etiology of these disorders can vary significantly, but emerging research highlights the crucial role of oxidative stress, an imbalance in the redox status characterized by an excess of reactive oxygen species (ROS), in driving cell death through apoptosis, autophagy, and inflammation. This review provides an overview of ROS-related processes underlying four extensively studied optic nerve diseases: glaucoma, Leber’s hereditary optic neuropathy (LHON), anterior ischemic optic neuropathy (AION), and optic neuritis (ON). Furthermore, we present preclinical findings on antioxidants, with the objective of evaluating the potential therapeutic benefits of targeting oxidative stress in the treatment of optic neuropathies.
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spelling pubmed-103761852023-07-29 Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases? Buonfiglio, Francesco Böhm, Elsa Wilma Pfeiffer, Norbert Gericke, Adrian Antioxidants (Basel) Review Optic nerve disorders encompass a wide spectrum of conditions characterized by the loss of retinal ganglion cells (RGCs) and subsequent degeneration of the optic nerve. The etiology of these disorders can vary significantly, but emerging research highlights the crucial role of oxidative stress, an imbalance in the redox status characterized by an excess of reactive oxygen species (ROS), in driving cell death through apoptosis, autophagy, and inflammation. This review provides an overview of ROS-related processes underlying four extensively studied optic nerve diseases: glaucoma, Leber’s hereditary optic neuropathy (LHON), anterior ischemic optic neuropathy (AION), and optic neuritis (ON). Furthermore, we present preclinical findings on antioxidants, with the objective of evaluating the potential therapeutic benefits of targeting oxidative stress in the treatment of optic neuropathies. MDPI 2023-07-20 /pmc/articles/PMC10376185/ /pubmed/37508003 http://dx.doi.org/10.3390/antiox12071465 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Buonfiglio, Francesco
Böhm, Elsa Wilma
Pfeiffer, Norbert
Gericke, Adrian
Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases?
title Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases?
title_full Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases?
title_fullStr Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases?
title_full_unstemmed Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases?
title_short Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases?
title_sort oxidative stress: a suitable therapeutic target for optic nerve diseases?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376185/
https://www.ncbi.nlm.nih.gov/pubmed/37508003
http://dx.doi.org/10.3390/antiox12071465
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