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Evidence of Placental Aging in Late SGA, Fetal Growth Restriction and Stillbirth—A Systematic Review

During pregnancy, the placenta undergoes a natural aging process, which is considered normal. However, it has been hypothesized that an abnormally accelerated and premature aging of the placenta may contribute to placenta-related health issues. Placental senescence has been linked to several obstetr...

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Autores principales: Kajdy, Anna, Sys, Dorota, Modzelewski, Jan, Bogusławska, Joanna, Cymbaluk-Płoska, Aneta, Kwiatkowska, Ewa, Bednarek-Jędrzejek, Magdalena, Borowski, Dariusz, Stefańska, Katarzyna, Rabijewski, Michał, Baran, Arkadiusz, Torbe, Andrzej, Feduniw, Stepan, Kwiatkowski, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376283/
https://www.ncbi.nlm.nih.gov/pubmed/37509425
http://dx.doi.org/10.3390/biomedicines11071785
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author Kajdy, Anna
Sys, Dorota
Modzelewski, Jan
Bogusławska, Joanna
Cymbaluk-Płoska, Aneta
Kwiatkowska, Ewa
Bednarek-Jędrzejek, Magdalena
Borowski, Dariusz
Stefańska, Katarzyna
Rabijewski, Michał
Baran, Arkadiusz
Torbe, Andrzej
Feduniw, Stepan
Kwiatkowski, Sebastian
author_facet Kajdy, Anna
Sys, Dorota
Modzelewski, Jan
Bogusławska, Joanna
Cymbaluk-Płoska, Aneta
Kwiatkowska, Ewa
Bednarek-Jędrzejek, Magdalena
Borowski, Dariusz
Stefańska, Katarzyna
Rabijewski, Michał
Baran, Arkadiusz
Torbe, Andrzej
Feduniw, Stepan
Kwiatkowski, Sebastian
author_sort Kajdy, Anna
collection PubMed
description During pregnancy, the placenta undergoes a natural aging process, which is considered normal. However, it has been hypothesized that an abnormally accelerated and premature aging of the placenta may contribute to placenta-related health issues. Placental senescence has been linked to several obstetric complications, including abnormal fetal growth, preeclampsia, preterm birth, and stillbirth, with stillbirth being the most challenging. A systematic search was conducted on Pubmed, Embase, and Scopus databases. Twenty-two full-text articles were identified for the final synthesis. Of these, 15 presented original research and 7 presented narrative reviews. There is a paucity of evidence in the literature on the role of placental aging in late small for gestational age (SGA), fetal growth restriction (FGR), and stillbirth. For future research, guidelines for both planning and reporting research must be implemented. The inclusion criteria should include clear differentiation between early and late SGA and FGR. As for stillbirths, only those with no other known cause of stillbirth should be included in the studies. This means excluding stillbirths due to congenital defects, infections, placental abruption, and maternal conditions affecting feto-maternal hemodynamics.
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spelling pubmed-103762832023-07-29 Evidence of Placental Aging in Late SGA, Fetal Growth Restriction and Stillbirth—A Systematic Review Kajdy, Anna Sys, Dorota Modzelewski, Jan Bogusławska, Joanna Cymbaluk-Płoska, Aneta Kwiatkowska, Ewa Bednarek-Jędrzejek, Magdalena Borowski, Dariusz Stefańska, Katarzyna Rabijewski, Michał Baran, Arkadiusz Torbe, Andrzej Feduniw, Stepan Kwiatkowski, Sebastian Biomedicines Systematic Review During pregnancy, the placenta undergoes a natural aging process, which is considered normal. However, it has been hypothesized that an abnormally accelerated and premature aging of the placenta may contribute to placenta-related health issues. Placental senescence has been linked to several obstetric complications, including abnormal fetal growth, preeclampsia, preterm birth, and stillbirth, with stillbirth being the most challenging. A systematic search was conducted on Pubmed, Embase, and Scopus databases. Twenty-two full-text articles were identified for the final synthesis. Of these, 15 presented original research and 7 presented narrative reviews. There is a paucity of evidence in the literature on the role of placental aging in late small for gestational age (SGA), fetal growth restriction (FGR), and stillbirth. For future research, guidelines for both planning and reporting research must be implemented. The inclusion criteria should include clear differentiation between early and late SGA and FGR. As for stillbirths, only those with no other known cause of stillbirth should be included in the studies. This means excluding stillbirths due to congenital defects, infections, placental abruption, and maternal conditions affecting feto-maternal hemodynamics. MDPI 2023-06-21 /pmc/articles/PMC10376283/ /pubmed/37509425 http://dx.doi.org/10.3390/biomedicines11071785 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Kajdy, Anna
Sys, Dorota
Modzelewski, Jan
Bogusławska, Joanna
Cymbaluk-Płoska, Aneta
Kwiatkowska, Ewa
Bednarek-Jędrzejek, Magdalena
Borowski, Dariusz
Stefańska, Katarzyna
Rabijewski, Michał
Baran, Arkadiusz
Torbe, Andrzej
Feduniw, Stepan
Kwiatkowski, Sebastian
Evidence of Placental Aging in Late SGA, Fetal Growth Restriction and Stillbirth—A Systematic Review
title Evidence of Placental Aging in Late SGA, Fetal Growth Restriction and Stillbirth—A Systematic Review
title_full Evidence of Placental Aging in Late SGA, Fetal Growth Restriction and Stillbirth—A Systematic Review
title_fullStr Evidence of Placental Aging in Late SGA, Fetal Growth Restriction and Stillbirth—A Systematic Review
title_full_unstemmed Evidence of Placental Aging in Late SGA, Fetal Growth Restriction and Stillbirth—A Systematic Review
title_short Evidence of Placental Aging in Late SGA, Fetal Growth Restriction and Stillbirth—A Systematic Review
title_sort evidence of placental aging in late sga, fetal growth restriction and stillbirth—a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376283/
https://www.ncbi.nlm.nih.gov/pubmed/37509425
http://dx.doi.org/10.3390/biomedicines11071785
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