Cargando…

Plant Exosome-like Nanovesicles and Their Role in the Innovative Delivery of RNA Therapeutics

Exosomes are single membrane-bound spheres released from cells carrying complex cargoes, including lipids, proteins, and nucleic acids. Exosomes transfer specific cargoes from donor to acceptor cells, playing important roles in cell-to-cell communication. Current studies have reported that plant exo...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Yu-Xin, Cai, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376343/
https://www.ncbi.nlm.nih.gov/pubmed/37509446
http://dx.doi.org/10.3390/biomedicines11071806
_version_ 1785079247557099520
author Chen, Yu-Xin
Cai, Qiang
author_facet Chen, Yu-Xin
Cai, Qiang
author_sort Chen, Yu-Xin
collection PubMed
description Exosomes are single membrane-bound spheres released from cells carrying complex cargoes, including lipids, proteins, and nucleic acids. Exosomes transfer specific cargoes from donor to acceptor cells, playing important roles in cell-to-cell communication. Current studies have reported that plant exosomes are prominent in transferring small RNA between host and pathogens in a cross-kingdom manner. Plant exosomes are excellent RNA interference (RNAi) delivery agents with similar physical and chemical properties to mammalian exosomes and have potential applications in therapeutic delivery systems. Recent data have suggested that plant exosome-like nanovesicles (PENVs) and artificial PENV-derived nano-vectors (APNVs) are beneficial for delivering therapeutic small RNA in mammalian systems and exhibit excellent competitiveness in future clinical applications. This review features their preparation methods, composition, roles in small RNA delivery for health functionalities, and their potency as functional nanomedicine.
format Online
Article
Text
id pubmed-10376343
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-103763432023-07-29 Plant Exosome-like Nanovesicles and Their Role in the Innovative Delivery of RNA Therapeutics Chen, Yu-Xin Cai, Qiang Biomedicines Review Exosomes are single membrane-bound spheres released from cells carrying complex cargoes, including lipids, proteins, and nucleic acids. Exosomes transfer specific cargoes from donor to acceptor cells, playing important roles in cell-to-cell communication. Current studies have reported that plant exosomes are prominent in transferring small RNA between host and pathogens in a cross-kingdom manner. Plant exosomes are excellent RNA interference (RNAi) delivery agents with similar physical and chemical properties to mammalian exosomes and have potential applications in therapeutic delivery systems. Recent data have suggested that plant exosome-like nanovesicles (PENVs) and artificial PENV-derived nano-vectors (APNVs) are beneficial for delivering therapeutic small RNA in mammalian systems and exhibit excellent competitiveness in future clinical applications. This review features their preparation methods, composition, roles in small RNA delivery for health functionalities, and their potency as functional nanomedicine. MDPI 2023-06-24 /pmc/articles/PMC10376343/ /pubmed/37509446 http://dx.doi.org/10.3390/biomedicines11071806 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chen, Yu-Xin
Cai, Qiang
Plant Exosome-like Nanovesicles and Their Role in the Innovative Delivery of RNA Therapeutics
title Plant Exosome-like Nanovesicles and Their Role in the Innovative Delivery of RNA Therapeutics
title_full Plant Exosome-like Nanovesicles and Their Role in the Innovative Delivery of RNA Therapeutics
title_fullStr Plant Exosome-like Nanovesicles and Their Role in the Innovative Delivery of RNA Therapeutics
title_full_unstemmed Plant Exosome-like Nanovesicles and Their Role in the Innovative Delivery of RNA Therapeutics
title_short Plant Exosome-like Nanovesicles and Their Role in the Innovative Delivery of RNA Therapeutics
title_sort plant exosome-like nanovesicles and their role in the innovative delivery of rna therapeutics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376343/
https://www.ncbi.nlm.nih.gov/pubmed/37509446
http://dx.doi.org/10.3390/biomedicines11071806
work_keys_str_mv AT chenyuxin plantexosomelikenanovesiclesandtheirroleintheinnovativedeliveryofrnatherapeutics
AT caiqiang plantexosomelikenanovesiclesandtheirroleintheinnovativedeliveryofrnatherapeutics