Cargando…

Aldehyde Dehydrogenase and Aldo-Keto Reductase Enzymes: Basic Concepts and Emerging Roles in Diabetic Retinopathy

Diabetic retinopathy (DR) is a complication of diabetes mellitus that can lead to vision loss and blindness. It is driven by various biochemical processes and molecular mechanisms, including lipid peroxidation and disrupted aldehyde metabolism, which contributes to retinal tissue damage and the prog...

Descripción completa

Detalles Bibliográficos
Autores principales:	Karan, Burak Mugdat, Little, Karis, Augustine, Josy, Stitt, Alan W., Curtis, Tim M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376360/ https://www.ncbi.nlm.nih.gov/pubmed/37508004 http://dx.doi.org/10.3390/antiox12071466

Ejemplares similares

Aldo-Keto Reductases in the Eye
por: Huang, Shun Ping, et al.
Publicado: (2010)

Regulation of Aldo–Keto Reductases in Human Diseases
por: Chen, Wei-Dong, et al.
Publicado: (2012)

Aldo-keto reductase (AKR) superfamily: Genomics and annotation
por: Mindnich, Rebekka D, et al.
Publicado: (2009)

Aldo-Keto Reductases 1B in Endocrinology and Metabolism
por: Pastel, Emilie, et al.
Publicado: (2012)

Acceleration of an aldo-keto reductase by minimal loop engineering
por: Krump, C., et al.
Publicado: (2014)

Role of Aldo–Keto Reductase Enzymes in Mediating the Timing of Parturition
por: Byrns, Michael C.
Publicado: (2012)

Aldo-Keto Reductases 1B in Adrenal Cortex Physiology
por: Pastel, Emilie, et al.
Publicado: (2016)

Semi-rational engineering an aldo–keto reductase for stereocomplementary reduction of α-keto amide compounds
por: Bai, Ruixuan, et al.
Publicado: (2023)

Biological Role of Aldo–Keto Reductases in Retinoic Acid Biosynthesis and Signaling
por: Ruiz, F. Xavier, et al.
Publicado: (2012)

Editorial on research topic: aldo-keto reductases and role in human disease
por: Jin, Yi
Publicado: (2013)

Human Aldo-Keto Reductases and the Metabolic Activation of Polycyclic Aromatic Hydrocarbons
por: Penning, Trevor M.
Publicado: (2014)

The Coptotermes gestroi aldo–keto reductase: a multipurpose enzyme for biorefinery applications
por: Tramontina, Robson, et al.
Publicado: (2017)

A role for trypanosomatid aldo-keto reductases in methylglyoxal, prostaglandin and isoprostane metabolism
por: Roberts, Adam J., et al.
Publicado: (2018)

Aldo‐keto reductase enzymes detoxify glyphosate and improve herbicide resistance in plants
por: Vemanna, Ramu S., et al.
Publicado: (2017)

Regulation of Gluconeogenesis by Aldo-keto-reductase 1a1b in Zebrafish
por: Li, Xiaogang, et al.
Publicado: (2020)

Structure–function characterization of an aldo–keto reductase involved in detoxification of the mycotoxin, deoxynivalenol
por: Abraham, Nadine, et al.
Publicado: (2022)

New Insights into the Role of the Trypanosoma cruzi Aldo-Keto Reductase TcAKR
por: Díaz-Viraqué, Florencia, et al.
Publicado: (2023)

Quantitative Evaluation of Aldo–keto Reductase Expression in Hepatocellular Carcinoma (HCC) Cell Lines
por: Yang, Lei, et al.
Publicado: (2013)

The Role of Cytochromes P450 and Aldo-Keto Reductases in Prognosis of Breast Carcinoma Patients
por: Hlaváč, Viktor, et al.
Publicado: (2014)

Effects of ligand binding on the stability of aldo–keto reductases: Implications for stabilizer or destabilizer chaperones
por: Kabir, Aurangazeb, et al.
Publicado: (2016)

Aldo‐keto reductases‐mediated cytotoxicity of 2‐deoxyglucose: A novel anticancer mechanism
por: Zhang, Shi‐Qing, et al.
Publicado: (2018)

Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis
por: Gagliardi, Mara, et al.
Publicado: (2019)

Perspective on the Structural Basis for Human Aldo-Keto Reductase 1B10 Inhibition
por: Ruiz, Francesc Xavier, et al.
Publicado: (2021)

Michaelis-Menten Kinetics Measurements of Aldo-Keto Reductases for Various Substrates in Murine Tissue
por: Morgenstern, Jakob, et al.
Publicado: (2020)

Aldo-Keto Reductase 1C15 Characterization and Protection in Ischemic Brain Injury
por: Yang, Tuo, et al.
Publicado: (2023)

Fluoxetine elevates allopregnanolone in female rat brain but inhibits a steroid microsomal dehydrogenase rather than activating an aldo-keto reductase
por: Fry, J P, et al.
Publicado: (2014)

Structural studies of codeinone reductase reveal novel insights into aldo-keto reductase function in benzylisoquinoline alkaloid biosynthesis
por: Carr, Samuel C., et al.
Publicado: (2021)

An aldo-keto reductase with 2-keto-l-gulonate reductase activity functions in l-tartaric acid biosynthesis from vitamin C in Vitis vinifera
por: Jia, Yong, et al.
Publicado: (2019)

Babesia microti Aldo-keto Reductase-Like Protein Involved in Antioxidant and Anti-parasite Response
por: Huang, Qiang, et al.
Publicado: (2017)

An aldo-keto reductase is responsible for Fusarium toxin-degrading activity in a soil Sphingomonas strain
por: He, Wei-Jie, et al.
Publicado: (2017)

Regulation Network and Prognostic Significance of Aldo-Keto Reductase (AKR) Superfamily Genes in Hepatocellular Carcinoma
por: Dai, Tianxing, et al.
Publicado: (2021)

Germline Mutations in Steroid Metabolizing Enzymes: A Focus on Steroid Transforming Aldo-Keto Reductases
por: Detlefsen, Andrea J., et al.
Publicado: (2023)

The Specific Binding and Promotion Effect of Azoles on Human Aldo-Keto Reductase 7A2
por: Wu, Wanying, et al.
Publicado: (2023)

Impact of cytotoxic chemotherapy on aldo-keto reductase family 1 member B10 expression
por: Robinson, Kathy, et al.
Publicado: (2023)

Chromosomal integration of aldo-keto-reductase and short-chain dehydrogenase/reductase genes in Clostridium beijerinckii NCIMB 8052 enhanced tolerance to lignocellulose-derived microbial inhibitory compounds
por: Okonkwo, Christopher Chukwudi, et al.
Publicado: (2019)

Aldo–Keto Reductase 1B10 and Its Role in Proliferation Capacity of Drug-Resistant Cancers
por: Matsunaga, Toshiyuki, et al.
Publicado: (2012)

Expression of Aldo-keto Reductase 1C23 in the Equine Corpus Luteum in Different Luteal Phases
por: KOZAI, Keisuke, et al.
Publicado: (2014)

Expression of Aldo-Keto Reductase Family 1 Member B10 in the Early Stages of Human Hepatocarcinogenesis
por: Tsuzura, Hironori, et al.
Publicado: (2014)

Aldo-Keto Reductase Family 1 Member B10 Inhibitors: Potential Drugs for Cancer Treatment
por: Huang, Li, et al.
Publicado: (2016)

Localization of an Aldo-Keto Reductase (AKR2E4) in the Silkworm Bombyx mori (Lepidoptera: Bombycidae)
por: Yamamoto, K, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_dgk1dlm7uvsvdt9pji1u6vpfdu