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Sixty-Month Follow Up of Clinical MRONJ Cases Treated with CGF and Piezosurgery
Aims: Medication-related osteonecrosis of the jaw (MRONJ) is a drug-related adverse reaction characterized by bone destruction and necrosis in the jaw. This case series aims to evaluate the treatment approaches and outcomes in MRONJ patients. Materials and methods: The retrospective study was conduc...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376556/ https://www.ncbi.nlm.nih.gov/pubmed/37508890 http://dx.doi.org/10.3390/bioengineering10070863 |
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author | Dipalma, Gianna Inchingolo, Angelo Michele Malcangi, Giuseppina Ferrara, Irene Viapiano, Fabio Netti, Anna Patano, Assunta Isacco, Ciro Gargiulo Inchingolo, Alessio Danilo Inchingolo, Francesco |
author_facet | Dipalma, Gianna Inchingolo, Angelo Michele Malcangi, Giuseppina Ferrara, Irene Viapiano, Fabio Netti, Anna Patano, Assunta Isacco, Ciro Gargiulo Inchingolo, Alessio Danilo Inchingolo, Francesco |
author_sort | Dipalma, Gianna |
collection | PubMed |
description | Aims: Medication-related osteonecrosis of the jaw (MRONJ) is a drug-related adverse reaction characterized by bone destruction and necrosis in the jaw. This case series aims to evaluate the treatment approaches and outcomes in MRONJ patients. Materials and methods: The retrospective study was conducted at the Dental Unit of the University of Bari, Italy. Patients with MRONJ were treated and followed up for 60 months. The treatment approach involved piezosurgery and concentrated growth factor (CGF). Six clinical cases from this group are described in detail. Results: None of the patients showed recurrence of necrotic MRONJ lesions during the follow-up period. The surgical interventions, including bone resections and the application of CGF, resulted in successful mucosal healing and the prevention of disease progression. Conclusions: This study highlights the complexity of managing MRONJ and the importance of a multidisciplinary approach. Conservative treatment options and minimally invasive surgery have shown efficacy in controlling symptoms and improving patients’ quality of life. However, the optimal treatment approach remains a challenge, and further studies are needed to evaluate alternative therapies and resective surgery. A comprehensive preoperative evaluation and collaboration among dental, endocrinology, and oncology specialists are crucial for personalized and multidisciplinary management. Ongoing research efforts are necessary to explore new therapeutic modalities and improve our understanding of MRONJ management, providing better support to patients dealing with this complex condition. |
format | Online Article Text |
id | pubmed-10376556 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103765562023-07-29 Sixty-Month Follow Up of Clinical MRONJ Cases Treated with CGF and Piezosurgery Dipalma, Gianna Inchingolo, Angelo Michele Malcangi, Giuseppina Ferrara, Irene Viapiano, Fabio Netti, Anna Patano, Assunta Isacco, Ciro Gargiulo Inchingolo, Alessio Danilo Inchingolo, Francesco Bioengineering (Basel) Article Aims: Medication-related osteonecrosis of the jaw (MRONJ) is a drug-related adverse reaction characterized by bone destruction and necrosis in the jaw. This case series aims to evaluate the treatment approaches and outcomes in MRONJ patients. Materials and methods: The retrospective study was conducted at the Dental Unit of the University of Bari, Italy. Patients with MRONJ were treated and followed up for 60 months. The treatment approach involved piezosurgery and concentrated growth factor (CGF). Six clinical cases from this group are described in detail. Results: None of the patients showed recurrence of necrotic MRONJ lesions during the follow-up period. The surgical interventions, including bone resections and the application of CGF, resulted in successful mucosal healing and the prevention of disease progression. Conclusions: This study highlights the complexity of managing MRONJ and the importance of a multidisciplinary approach. Conservative treatment options and minimally invasive surgery have shown efficacy in controlling symptoms and improving patients’ quality of life. However, the optimal treatment approach remains a challenge, and further studies are needed to evaluate alternative therapies and resective surgery. A comprehensive preoperative evaluation and collaboration among dental, endocrinology, and oncology specialists are crucial for personalized and multidisciplinary management. Ongoing research efforts are necessary to explore new therapeutic modalities and improve our understanding of MRONJ management, providing better support to patients dealing with this complex condition. MDPI 2023-07-20 /pmc/articles/PMC10376556/ /pubmed/37508890 http://dx.doi.org/10.3390/bioengineering10070863 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Dipalma, Gianna Inchingolo, Angelo Michele Malcangi, Giuseppina Ferrara, Irene Viapiano, Fabio Netti, Anna Patano, Assunta Isacco, Ciro Gargiulo Inchingolo, Alessio Danilo Inchingolo, Francesco Sixty-Month Follow Up of Clinical MRONJ Cases Treated with CGF and Piezosurgery |
title | Sixty-Month Follow Up of Clinical MRONJ Cases Treated with CGF and Piezosurgery |
title_full | Sixty-Month Follow Up of Clinical MRONJ Cases Treated with CGF and Piezosurgery |
title_fullStr | Sixty-Month Follow Up of Clinical MRONJ Cases Treated with CGF and Piezosurgery |
title_full_unstemmed | Sixty-Month Follow Up of Clinical MRONJ Cases Treated with CGF and Piezosurgery |
title_short | Sixty-Month Follow Up of Clinical MRONJ Cases Treated with CGF and Piezosurgery |
title_sort | sixty-month follow up of clinical mronj cases treated with cgf and piezosurgery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376556/ https://www.ncbi.nlm.nih.gov/pubmed/37508890 http://dx.doi.org/10.3390/bioengineering10070863 |
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