Cargando…

Corneal Surface Wave Propagation Associated with Intraocular Pressures: OCT Elastography Assessment in a Simplified Eye Model

Assessing corneal biomechanics in vivo has long been a challenge in the field of ophthalmology. Despite recent advances in optical coherence tomography (OCT)-based elastography (OCE) methods, controversy remains regarding the effect of intraocular pressure (IOP) on mechanical wave propagation speed...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Guoqin, Cai, Jing, Zhong, Rijian, He, Weichao, Ye, Haoxi, Duvvuri, Chaitanya, Song, Chengjin, Feng, Jinping, An, Lin, Qin, Jia, Huang, Yanping, Xu, Jingjiang, Twa, Michael D., Lan, Gongpu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376591/
https://www.ncbi.nlm.nih.gov/pubmed/37508781
http://dx.doi.org/10.3390/bioengineering10070754
_version_ 1785079309607632896
author Ma, Guoqin
Cai, Jing
Zhong, Rijian
He, Weichao
Ye, Haoxi
Duvvuri, Chaitanya
Song, Chengjin
Feng, Jinping
An, Lin
Qin, Jia
Huang, Yanping
Xu, Jingjiang
Twa, Michael D.
Lan, Gongpu
author_facet Ma, Guoqin
Cai, Jing
Zhong, Rijian
He, Weichao
Ye, Haoxi
Duvvuri, Chaitanya
Song, Chengjin
Feng, Jinping
An, Lin
Qin, Jia
Huang, Yanping
Xu, Jingjiang
Twa, Michael D.
Lan, Gongpu
author_sort Ma, Guoqin
collection PubMed
description Assessing corneal biomechanics in vivo has long been a challenge in the field of ophthalmology. Despite recent advances in optical coherence tomography (OCT)-based elastography (OCE) methods, controversy remains regarding the effect of intraocular pressure (IOP) on mechanical wave propagation speed in the cornea. This could be attributed to the complexity of corneal biomechanics and the difficulties associated with conducting in vivo corneal shear-wave OCE measurements. We constructed a simplified artificial eye model with a silicone cornea and controllable IOPs and performed surface wave OCE measurements in radial directions (54–324°) of the silicone cornea at different IOP levels (10–40 mmHg). The results demonstrated increases in wave propagation speeds (mean ± STD) from 6.55 ± 0.09 m/s (10 mmHg) to 9.82 ± 0.19 m/s (40 mmHg), leading to an estimate of Young’s modulus, which increased from 145.23 ± 4.43 kPa to 326.44 ± 13.30 kPa. Our implementation of an artificial eye model highlighted that the impact of IOP on Young’s modulus (ΔE = 165.59 kPa, IOP: 10–40 mmHg) was more significant than the effect of stretching of the silicone cornea (ΔE = 15.79 kPa, relative elongation: 0.98–6.49%). Our study sheds light on the potential advantages of using an artificial eye model to represent the response of the human cornea during OCE measurement and provides valuable insights into the impact of IOP on wave-based OCE measurement for future in vivo corneal biomechanics studies.
format Online
Article
Text
id pubmed-10376591
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-103765912023-07-29 Corneal Surface Wave Propagation Associated with Intraocular Pressures: OCT Elastography Assessment in a Simplified Eye Model Ma, Guoqin Cai, Jing Zhong, Rijian He, Weichao Ye, Haoxi Duvvuri, Chaitanya Song, Chengjin Feng, Jinping An, Lin Qin, Jia Huang, Yanping Xu, Jingjiang Twa, Michael D. Lan, Gongpu Bioengineering (Basel) Article Assessing corneal biomechanics in vivo has long been a challenge in the field of ophthalmology. Despite recent advances in optical coherence tomography (OCT)-based elastography (OCE) methods, controversy remains regarding the effect of intraocular pressure (IOP) on mechanical wave propagation speed in the cornea. This could be attributed to the complexity of corneal biomechanics and the difficulties associated with conducting in vivo corneal shear-wave OCE measurements. We constructed a simplified artificial eye model with a silicone cornea and controllable IOPs and performed surface wave OCE measurements in radial directions (54–324°) of the silicone cornea at different IOP levels (10–40 mmHg). The results demonstrated increases in wave propagation speeds (mean ± STD) from 6.55 ± 0.09 m/s (10 mmHg) to 9.82 ± 0.19 m/s (40 mmHg), leading to an estimate of Young’s modulus, which increased from 145.23 ± 4.43 kPa to 326.44 ± 13.30 kPa. Our implementation of an artificial eye model highlighted that the impact of IOP on Young’s modulus (ΔE = 165.59 kPa, IOP: 10–40 mmHg) was more significant than the effect of stretching of the silicone cornea (ΔE = 15.79 kPa, relative elongation: 0.98–6.49%). Our study sheds light on the potential advantages of using an artificial eye model to represent the response of the human cornea during OCE measurement and provides valuable insights into the impact of IOP on wave-based OCE measurement for future in vivo corneal biomechanics studies. MDPI 2023-06-24 /pmc/articles/PMC10376591/ /pubmed/37508781 http://dx.doi.org/10.3390/bioengineering10070754 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ma, Guoqin
Cai, Jing
Zhong, Rijian
He, Weichao
Ye, Haoxi
Duvvuri, Chaitanya
Song, Chengjin
Feng, Jinping
An, Lin
Qin, Jia
Huang, Yanping
Xu, Jingjiang
Twa, Michael D.
Lan, Gongpu
Corneal Surface Wave Propagation Associated with Intraocular Pressures: OCT Elastography Assessment in a Simplified Eye Model
title Corneal Surface Wave Propagation Associated with Intraocular Pressures: OCT Elastography Assessment in a Simplified Eye Model
title_full Corneal Surface Wave Propagation Associated with Intraocular Pressures: OCT Elastography Assessment in a Simplified Eye Model
title_fullStr Corneal Surface Wave Propagation Associated with Intraocular Pressures: OCT Elastography Assessment in a Simplified Eye Model
title_full_unstemmed Corneal Surface Wave Propagation Associated with Intraocular Pressures: OCT Elastography Assessment in a Simplified Eye Model
title_short Corneal Surface Wave Propagation Associated with Intraocular Pressures: OCT Elastography Assessment in a Simplified Eye Model
title_sort corneal surface wave propagation associated with intraocular pressures: oct elastography assessment in a simplified eye model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376591/
https://www.ncbi.nlm.nih.gov/pubmed/37508781
http://dx.doi.org/10.3390/bioengineering10070754
work_keys_str_mv AT maguoqin cornealsurfacewavepropagationassociatedwithintraocularpressuresoctelastographyassessmentinasimplifiedeyemodel
AT caijing cornealsurfacewavepropagationassociatedwithintraocularpressuresoctelastographyassessmentinasimplifiedeyemodel
AT zhongrijian cornealsurfacewavepropagationassociatedwithintraocularpressuresoctelastographyassessmentinasimplifiedeyemodel
AT heweichao cornealsurfacewavepropagationassociatedwithintraocularpressuresoctelastographyassessmentinasimplifiedeyemodel
AT yehaoxi cornealsurfacewavepropagationassociatedwithintraocularpressuresoctelastographyassessmentinasimplifiedeyemodel
AT duvvurichaitanya cornealsurfacewavepropagationassociatedwithintraocularpressuresoctelastographyassessmentinasimplifiedeyemodel
AT songchengjin cornealsurfacewavepropagationassociatedwithintraocularpressuresoctelastographyassessmentinasimplifiedeyemodel
AT fengjinping cornealsurfacewavepropagationassociatedwithintraocularpressuresoctelastographyassessmentinasimplifiedeyemodel
AT anlin cornealsurfacewavepropagationassociatedwithintraocularpressuresoctelastographyassessmentinasimplifiedeyemodel
AT qinjia cornealsurfacewavepropagationassociatedwithintraocularpressuresoctelastographyassessmentinasimplifiedeyemodel
AT huangyanping cornealsurfacewavepropagationassociatedwithintraocularpressuresoctelastographyassessmentinasimplifiedeyemodel
AT xujingjiang cornealsurfacewavepropagationassociatedwithintraocularpressuresoctelastographyassessmentinasimplifiedeyemodel
AT twamichaeld cornealsurfacewavepropagationassociatedwithintraocularpressuresoctelastographyassessmentinasimplifiedeyemodel
AT langongpu cornealsurfacewavepropagationassociatedwithintraocularpressuresoctelastographyassessmentinasimplifiedeyemodel