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Corneal Surface Wave Propagation Associated with Intraocular Pressures: OCT Elastography Assessment in a Simplified Eye Model
Assessing corneal biomechanics in vivo has long been a challenge in the field of ophthalmology. Despite recent advances in optical coherence tomography (OCT)-based elastography (OCE) methods, controversy remains regarding the effect of intraocular pressure (IOP) on mechanical wave propagation speed...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376591/ https://www.ncbi.nlm.nih.gov/pubmed/37508781 http://dx.doi.org/10.3390/bioengineering10070754 |
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author | Ma, Guoqin Cai, Jing Zhong, Rijian He, Weichao Ye, Haoxi Duvvuri, Chaitanya Song, Chengjin Feng, Jinping An, Lin Qin, Jia Huang, Yanping Xu, Jingjiang Twa, Michael D. Lan, Gongpu |
author_facet | Ma, Guoqin Cai, Jing Zhong, Rijian He, Weichao Ye, Haoxi Duvvuri, Chaitanya Song, Chengjin Feng, Jinping An, Lin Qin, Jia Huang, Yanping Xu, Jingjiang Twa, Michael D. Lan, Gongpu |
author_sort | Ma, Guoqin |
collection | PubMed |
description | Assessing corneal biomechanics in vivo has long been a challenge in the field of ophthalmology. Despite recent advances in optical coherence tomography (OCT)-based elastography (OCE) methods, controversy remains regarding the effect of intraocular pressure (IOP) on mechanical wave propagation speed in the cornea. This could be attributed to the complexity of corneal biomechanics and the difficulties associated with conducting in vivo corneal shear-wave OCE measurements. We constructed a simplified artificial eye model with a silicone cornea and controllable IOPs and performed surface wave OCE measurements in radial directions (54–324°) of the silicone cornea at different IOP levels (10–40 mmHg). The results demonstrated increases in wave propagation speeds (mean ± STD) from 6.55 ± 0.09 m/s (10 mmHg) to 9.82 ± 0.19 m/s (40 mmHg), leading to an estimate of Young’s modulus, which increased from 145.23 ± 4.43 kPa to 326.44 ± 13.30 kPa. Our implementation of an artificial eye model highlighted that the impact of IOP on Young’s modulus (ΔE = 165.59 kPa, IOP: 10–40 mmHg) was more significant than the effect of stretching of the silicone cornea (ΔE = 15.79 kPa, relative elongation: 0.98–6.49%). Our study sheds light on the potential advantages of using an artificial eye model to represent the response of the human cornea during OCE measurement and provides valuable insights into the impact of IOP on wave-based OCE measurement for future in vivo corneal biomechanics studies. |
format | Online Article Text |
id | pubmed-10376591 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103765912023-07-29 Corneal Surface Wave Propagation Associated with Intraocular Pressures: OCT Elastography Assessment in a Simplified Eye Model Ma, Guoqin Cai, Jing Zhong, Rijian He, Weichao Ye, Haoxi Duvvuri, Chaitanya Song, Chengjin Feng, Jinping An, Lin Qin, Jia Huang, Yanping Xu, Jingjiang Twa, Michael D. Lan, Gongpu Bioengineering (Basel) Article Assessing corneal biomechanics in vivo has long been a challenge in the field of ophthalmology. Despite recent advances in optical coherence tomography (OCT)-based elastography (OCE) methods, controversy remains regarding the effect of intraocular pressure (IOP) on mechanical wave propagation speed in the cornea. This could be attributed to the complexity of corneal biomechanics and the difficulties associated with conducting in vivo corneal shear-wave OCE measurements. We constructed a simplified artificial eye model with a silicone cornea and controllable IOPs and performed surface wave OCE measurements in radial directions (54–324°) of the silicone cornea at different IOP levels (10–40 mmHg). The results demonstrated increases in wave propagation speeds (mean ± STD) from 6.55 ± 0.09 m/s (10 mmHg) to 9.82 ± 0.19 m/s (40 mmHg), leading to an estimate of Young’s modulus, which increased from 145.23 ± 4.43 kPa to 326.44 ± 13.30 kPa. Our implementation of an artificial eye model highlighted that the impact of IOP on Young’s modulus (ΔE = 165.59 kPa, IOP: 10–40 mmHg) was more significant than the effect of stretching of the silicone cornea (ΔE = 15.79 kPa, relative elongation: 0.98–6.49%). Our study sheds light on the potential advantages of using an artificial eye model to represent the response of the human cornea during OCE measurement and provides valuable insights into the impact of IOP on wave-based OCE measurement for future in vivo corneal biomechanics studies. MDPI 2023-06-24 /pmc/articles/PMC10376591/ /pubmed/37508781 http://dx.doi.org/10.3390/bioengineering10070754 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ma, Guoqin Cai, Jing Zhong, Rijian He, Weichao Ye, Haoxi Duvvuri, Chaitanya Song, Chengjin Feng, Jinping An, Lin Qin, Jia Huang, Yanping Xu, Jingjiang Twa, Michael D. Lan, Gongpu Corneal Surface Wave Propagation Associated with Intraocular Pressures: OCT Elastography Assessment in a Simplified Eye Model |
title | Corneal Surface Wave Propagation Associated with Intraocular Pressures: OCT Elastography Assessment in a Simplified Eye Model |
title_full | Corneal Surface Wave Propagation Associated with Intraocular Pressures: OCT Elastography Assessment in a Simplified Eye Model |
title_fullStr | Corneal Surface Wave Propagation Associated with Intraocular Pressures: OCT Elastography Assessment in a Simplified Eye Model |
title_full_unstemmed | Corneal Surface Wave Propagation Associated with Intraocular Pressures: OCT Elastography Assessment in a Simplified Eye Model |
title_short | Corneal Surface Wave Propagation Associated with Intraocular Pressures: OCT Elastography Assessment in a Simplified Eye Model |
title_sort | corneal surface wave propagation associated with intraocular pressures: oct elastography assessment in a simplified eye model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376591/ https://www.ncbi.nlm.nih.gov/pubmed/37508781 http://dx.doi.org/10.3390/bioengineering10070754 |
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