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Time-resolved molecular measurements reveal changes in astronauts during spaceflight
From the early days of spaceflight to current missions, astronauts continue to be exposed to multiple hazards that affect human health, including low gravity, high radiation, isolation during long-duration missions, a closed environment and distance from Earth. Their effects can lead to adverse phys...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376710/ https://www.ncbi.nlm.nih.gov/pubmed/37520819 http://dx.doi.org/10.3389/fphys.2023.1219221 |
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author | Zheng, Minzhang Charvat, Jacqueline Zwart, Sara R. Mehta, Satish K. Crucian, Brian E. Smith, Scott M. He, Jin Piermarocchi, Carlo Mias, George I. |
author_facet | Zheng, Minzhang Charvat, Jacqueline Zwart, Sara R. Mehta, Satish K. Crucian, Brian E. Smith, Scott M. He, Jin Piermarocchi, Carlo Mias, George I. |
author_sort | Zheng, Minzhang |
collection | PubMed |
description | From the early days of spaceflight to current missions, astronauts continue to be exposed to multiple hazards that affect human health, including low gravity, high radiation, isolation during long-duration missions, a closed environment and distance from Earth. Their effects can lead to adverse physiological changes and necessitate countermeasure development and/or longitudinal monitoring. A time-resolved analysis of biological signals can detect and better characterize potential adverse events during spaceflight, ideally preventing them and maintaining astronauts’ wellness. Here we provide a time-resolved assessment of the impact of spaceflight on multiple astronauts (n = 27) by studying multiple biochemical and immune measurements before, during, and after long-duration orbital spaceflight. We reveal space-associated changes of astronauts’ physiology on both the individual level and across astronauts, including associations with bone resorption and kidney function, as well as immune-system dysregulation. |
format | Online Article Text |
id | pubmed-10376710 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103767102023-07-29 Time-resolved molecular measurements reveal changes in astronauts during spaceflight Zheng, Minzhang Charvat, Jacqueline Zwart, Sara R. Mehta, Satish K. Crucian, Brian E. Smith, Scott M. He, Jin Piermarocchi, Carlo Mias, George I. Front Physiol Physiology From the early days of spaceflight to current missions, astronauts continue to be exposed to multiple hazards that affect human health, including low gravity, high radiation, isolation during long-duration missions, a closed environment and distance from Earth. Their effects can lead to adverse physiological changes and necessitate countermeasure development and/or longitudinal monitoring. A time-resolved analysis of biological signals can detect and better characterize potential adverse events during spaceflight, ideally preventing them and maintaining astronauts’ wellness. Here we provide a time-resolved assessment of the impact of spaceflight on multiple astronauts (n = 27) by studying multiple biochemical and immune measurements before, during, and after long-duration orbital spaceflight. We reveal space-associated changes of astronauts’ physiology on both the individual level and across astronauts, including associations with bone resorption and kidney function, as well as immune-system dysregulation. Frontiers Media S.A. 2023-07-14 /pmc/articles/PMC10376710/ /pubmed/37520819 http://dx.doi.org/10.3389/fphys.2023.1219221 Text en Copyright © 2023 United States Government as represented by the Administrator of the National Aeronautics and Space Administration and Minzhang Zheng, Jacqueline Charvat, Jin He, Carlo Piermarocchi and George I. Mias. At least a portion of this work is authored by Sara R. Zwart, Satish K. Mehta, Brian E. Crucian, and Scott M. Smith on behalf of the U.S government and, as regards Dr. Zwart, Dr. Mehta, Dr. Crucian, Dr. Smith, U.S. copyright protection does not attach to separable portions of a Work authored solely by U.S. Government employees as part of their official duties. The U.S. Government is the owner of foreign copyrights in such separable portions of the Work and is a joint owner (with any non-U.S. Government author) of U.S. and foreign copyrights that may be asserted in inseparable portions the Work. The U.S. Government retains the right to use, reproduce, distribute, create derivative works, perform, and display portions of the Work authored solely or co-authored by a U.S. Government employee. Non-U.S copyrights also apply. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Zheng, Minzhang Charvat, Jacqueline Zwart, Sara R. Mehta, Satish K. Crucian, Brian E. Smith, Scott M. He, Jin Piermarocchi, Carlo Mias, George I. Time-resolved molecular measurements reveal changes in astronauts during spaceflight |
title | Time-resolved molecular measurements reveal changes in astronauts during spaceflight |
title_full | Time-resolved molecular measurements reveal changes in astronauts during spaceflight |
title_fullStr | Time-resolved molecular measurements reveal changes in astronauts during spaceflight |
title_full_unstemmed | Time-resolved molecular measurements reveal changes in astronauts during spaceflight |
title_short | Time-resolved molecular measurements reveal changes in astronauts during spaceflight |
title_sort | time-resolved molecular measurements reveal changes in astronauts during spaceflight |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376710/ https://www.ncbi.nlm.nih.gov/pubmed/37520819 http://dx.doi.org/10.3389/fphys.2023.1219221 |
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