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Revolutionizing bone regeneration: advanced biomaterials for healing compromised bone defects

In this review, we explore the application of novel biomaterial-based therapies specifically targeted towards craniofacial bone defects. The repair and regeneration of critical sized bone defects in the craniofacial region requires the use of bioactive materials to stabilize and expedite the healing...

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Autores principales: Awad, Kamal, Ahuja, Neelam, Yacoub, Ahmed S., Brotto, Leticia, Young, Simon, Mikos, Antonios, Aswath, Pranesh, Varanasi, Venu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376722/
https://www.ncbi.nlm.nih.gov/pubmed/37520216
http://dx.doi.org/10.3389/fragi.2023.1217054
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author Awad, Kamal
Ahuja, Neelam
Yacoub, Ahmed S.
Brotto, Leticia
Young, Simon
Mikos, Antonios
Aswath, Pranesh
Varanasi, Venu
author_facet Awad, Kamal
Ahuja, Neelam
Yacoub, Ahmed S.
Brotto, Leticia
Young, Simon
Mikos, Antonios
Aswath, Pranesh
Varanasi, Venu
author_sort Awad, Kamal
collection PubMed
description In this review, we explore the application of novel biomaterial-based therapies specifically targeted towards craniofacial bone defects. The repair and regeneration of critical sized bone defects in the craniofacial region requires the use of bioactive materials to stabilize and expedite the healing process. However, the existing clinical approaches face challenges in effectively treating complex craniofacial bone defects, including issues such as oxidative stress, inflammation, and soft tissue loss. Given that a significant portion of individuals affected by traumatic bone defects in the craniofacial area belong to the aging population, there is an urgent need for innovative biomaterials to address the declining rate of new bone formation associated with age-related changes in the skeletal system. This article emphasizes the importance of semiconductor industry-derived materials as a potential solution to combat oxidative stress and address the challenges associated with aging bone. Furthermore, we discuss various material and autologous treatment approaches, as well as in vitro and in vivo models used to investigate new therapeutic strategies in the context of craniofacial bone repair. By focusing on these aspects, we aim to shed light on the potential of advanced biomaterials to overcome the limitations of current treatments and pave the way for more effective and efficient therapeutic interventions for craniofacial bone defects.
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spelling pubmed-103767222023-07-29 Revolutionizing bone regeneration: advanced biomaterials for healing compromised bone defects Awad, Kamal Ahuja, Neelam Yacoub, Ahmed S. Brotto, Leticia Young, Simon Mikos, Antonios Aswath, Pranesh Varanasi, Venu Front Aging Aging In this review, we explore the application of novel biomaterial-based therapies specifically targeted towards craniofacial bone defects. The repair and regeneration of critical sized bone defects in the craniofacial region requires the use of bioactive materials to stabilize and expedite the healing process. However, the existing clinical approaches face challenges in effectively treating complex craniofacial bone defects, including issues such as oxidative stress, inflammation, and soft tissue loss. Given that a significant portion of individuals affected by traumatic bone defects in the craniofacial area belong to the aging population, there is an urgent need for innovative biomaterials to address the declining rate of new bone formation associated with age-related changes in the skeletal system. This article emphasizes the importance of semiconductor industry-derived materials as a potential solution to combat oxidative stress and address the challenges associated with aging bone. Furthermore, we discuss various material and autologous treatment approaches, as well as in vitro and in vivo models used to investigate new therapeutic strategies in the context of craniofacial bone repair. By focusing on these aspects, we aim to shed light on the potential of advanced biomaterials to overcome the limitations of current treatments and pave the way for more effective and efficient therapeutic interventions for craniofacial bone defects. Frontiers Media S.A. 2023-07-14 /pmc/articles/PMC10376722/ /pubmed/37520216 http://dx.doi.org/10.3389/fragi.2023.1217054 Text en Copyright © 2023 Awad, Ahuja, Yacoub, Brotto, Young, Mikos, Aswath and Varanasi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging
Awad, Kamal
Ahuja, Neelam
Yacoub, Ahmed S.
Brotto, Leticia
Young, Simon
Mikos, Antonios
Aswath, Pranesh
Varanasi, Venu
Revolutionizing bone regeneration: advanced biomaterials for healing compromised bone defects
title Revolutionizing bone regeneration: advanced biomaterials for healing compromised bone defects
title_full Revolutionizing bone regeneration: advanced biomaterials for healing compromised bone defects
title_fullStr Revolutionizing bone regeneration: advanced biomaterials for healing compromised bone defects
title_full_unstemmed Revolutionizing bone regeneration: advanced biomaterials for healing compromised bone defects
title_short Revolutionizing bone regeneration: advanced biomaterials for healing compromised bone defects
title_sort revolutionizing bone regeneration: advanced biomaterials for healing compromised bone defects
topic Aging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376722/
https://www.ncbi.nlm.nih.gov/pubmed/37520216
http://dx.doi.org/10.3389/fragi.2023.1217054
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